Myocardial remodeling after infarction: the role of myofibroblasts

By Susanne W M van den Borne, J. Dı́ez, W. Blankesteijn, Johan Verjans, L. Hofstra, J. Narula. Nature Reviews Cardiology, 2010

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Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration (2016, background): “In cultured fibroblasts, BNP decreases collagen synthesis and up-regulates MMP expression (Tsuruda et al. 2002).”
The myofibroblast matrix: implications for tissue repair and fibrosis (2013, neutral): “The contribution of myofibroblastsand their elaborated ECM to normal and pathologic tissue repair [3]has been well-studied in lung [4-6], liver [7-9], kidney [10,11], skeletal muscle [12], systemic sclerosis [13-15], heart [16-18], and the stromal reaction to tumours[19,20].”
Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. (2012, background): “In addition to these organs, myofibroblasts play a substantial role promoting heart fibrosis and vascular remodeling, but because of space limitation, these topics are not covered herein, and we refer the reader to recent reviews of this rapidly growing body of literature.(4,5) Another fibrotic cond”
Matrix metalloproteinase-9: Many shades of function in cardiovascular disease. (2013, background): “Myofibroblasts produce ECM and are able to contract, thus contributing to tissue replacement and scar formation post-MI (FIGURE 3) (121).”