Nanotopography-guided tissue engineering and regenerative medicine
By Hong Nam Kim, Alex Jiao, Nathaniel S. Hwang, Min Sung Kim, D. Kang, Deok‐Ho Kim, Kahp Y. Suh. Advanced Drug Delivery Reviews, 2012
371 citations recorded by the source corpus.
Human tissues are intricate ensembles of multiple cell types embedded in complex and well-defined structures of the extracellular matrix (ECM). The organization of ECM is frequently hierarchical from nano to macro, with many proteins forming large scale structures with feature sizes up to several hundred microns. Inspired from these natural designs of ECM, nanotopography-guided approaches have been increasingly investigated for the last several decades. Results demonstrate that the nanotopography itself can activate tissue-specific function in vitro as well as promote tissue regeneration in vivo upon transplantation. In this review, we provide an extensive analysis of recent efforts to mimic functional nanostructures in vitro for improved tissue engineering and regeneration of injured and damaged tissues. We first characterize the role of various nanostructures in human tissues with respect to each tissue-specific function. Then, we describe various fabrication methods in terms of patterning principles and material characteristics. Finally, we summarize the applications of nanotopography to various tissues, which are classified into four types depending on their functions: protective, mechano-sensitive, electro-active, and shear stress-sensitive tissues. Some limitations and future challenges are briefly discussed at the end.
Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience
View Paper: https://www.semanticscholar.org/paper/bd9da9b68a49e63416fb25fd30bd674cdeaf888a
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In Biomedical Engineering
Citations in the corpus
- Nano and Microscale Topographies for the Prevention of Bacterial Surface Fouling (2014, background): “However, many of those nanostructured surfaces were fabricated with the intent of replicating the 3D scaffold-like structure of the extra cellular matrix (ECM) in efforts of promoting mammalian cell differentiation and proliferation [93–97].”
- 3D Bioprinting for Engineering Complex Tissues (2015, methodology): “Motivatedbydevelopmentsinnanotechnology,techniques likeself-assembly and soft-lithographyhave been applied to bottom-up tissue engineering(Kim et al., 2013,2014a; Shapiraet al.,2014).”