Innate antimicrobial peptide protects the skin from invasive bacterial infection

By V. Nizet, T. Ohtake, X. Lauth, J. Trowbridge, Jennifer A. Rudisill, R. Dorschner, V. Pestonjamasp, J. Piraino, K. Huttner, R. Gallo. Nature, 2001

1,281 citations recorded by the source corpus.

Subfields: Immunology, Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/10ae9a2a172e8740e01fe596b8a6658d93f71e69

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Citations in the corpus

Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea (2007, background): “, and are known for their functions to protect the host against infection by Gram-positiv”
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin (2003, background): “Mice rendered deficient in the expression of the antimicrobial peptide cathelin-related antimicrobial peptide (CRAMP) were more susceptible to skin infections by group A Streptococcus”
Antimicrobial Peptides: An Emerging Category of Therapeutic Agents (2016, background): “…is further demonstrated by the increased infection susceptibility of mice genetically modified to lack the gene encoding for the mouse analog of the humanAMP LL-37 (Nizet et al., 2001) and of humans with diseases associated with reduced AMP production such as atopic dermatitis (Ong et al., 2002).”
The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection (2006, background): “Gene-deficient models have confirmed the importance of cathelicidin in protection of ski”
Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection (2005, background): “The functional importance of antimicrobial peptides in innate cutaneous host defense is demonstrated by the increased susceptibility to infection with Group A streptococcae of mice with knockout of the mouse ortholog of the human cathelicidin gene CAMP”
Wound repair and regeneration: Mechanisms, signaling, and translation (2014, neutral): “2) (36, 37).”
Stratum corneum defensive functions: an integrated view. (2005, background): “The biologic importance of cathelicidins in antimicrobial defense is shown by the increased incidence of skin infections in knockout mice”
Cytokine Milieu of Atopic Dermatitis, as Compared to Psoriasis, Skin Prevents Induction of Innate Immune Response Genes 1 (2003, background): “peptide expression is essential for skin to combat infection (9, 10).”
Defensins: antimicrobial peptides of innate immunity (2003, background): “Mice with homozygous disruption of the Cramp gene showed diminished resistance to skin infection with group A Streptococcus”
Multifunctional cationic host defence peptides and their clinical applications (2011, background): “aeruginosa, Staphylococcus aureus, and group A Streptococcus [10, 18, 77, 78].”
Cathelicidins, multifunctional peptides of the innate immunity (2004, background): “Indirect evidence that endogenous expression of LL-37 protects from skin infections comes from the demonstration that mice null for the CRAMP cathelicidin gene are much more susceptible to skin infection by group A Streptococcus than wild-type mice are [86].”
A component of innate immunity prevents bacterial biofilm development (2002, background): “These factors can rapidly kill bacteria deposited on mucosal surfaces and prevent acute invasive infection”