Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection

By R. Gläser, J. Harder, H. Lange, J. Bartels, E. Christophers, J. Schröder. Nature Immunology, 2005

660 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Antimicrobial peptides: The ancient arm of the human immune system (2010, background): “coli while the skin-resident bacterium Staphylococcus epidermidis is much less susceptible.(50) Binding of flagellin from E.”
Zinc in Infection and Inflammation (2017, background): “Several cell types secrete different peptides, keratinocytes secrete S100A7 that can kill Escherichia coli by sequestering zinc [94].”
Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. (2005, background): “In this very context, exciting new studies have elucidated that an S100 family member, S100A7, protects skin from E. coli infection (Glaser et al., 2005).”
Nutritional immunity beyond iron: a role for manganese and zinc (2009, background): “The keratinocyte proteins S100A7 (psoriacin) and S100A15 also have antimicrobial activity [57,58].”
Functions of S100 Proteins (2012, background): “coli survival; the hinge region (amino acids 35-80) is sufficient for full activity [203,204].”