Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin

By Nita H. Salzman, D. Ghosh, K. Huttner, Y. Paterson, C. Bevins. Nature, 2003

798 citations recorded by the source corpus.

Subfields: Immunology, Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/14d887509be94342193b22a7f80733bb68520691

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Citations in the corpus

Mechanisms and consequences of bacterial resistance to antimicrobial peptides. (2016, background): “Evidence for their antibacterial efficacy in vivo comes from studies using infections in animal models (Huang et al., 2002), and also from infection studies using transgenic or knockout mice defective in the production of various AMPs (Moser et al., 2002; Salzman et al., 2003; Wilson et al., 1999).”
Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface (2008, result): “These findings are consistent with prior studies showing that Paneth cell -defensins protect against Salmonella-induced pathogenicity (27, 28).”
Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo (2018, background): “Knockout and transgenic mice experiments have indicated that α defensins are critical for protection against Escherichia coli [46] and Salmonella enterica [47].”
The composition of the gut microbiota throughout life, with an emphasis on early life (2015, background): “These include, among others, mucus production and mucin glycan modification (see next section ‘Mucin glycosylation’), bile metabolism (75), host-derived antimicrobial peptides (76), and mammalian hormones (77, 78).”
NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal α-defensin expression (2004, background): “As some specific bacteria may downregulate defensin expression”
Peptide Antimicrobial Agents (2006, background): “mouse Paneth cells conferred immunity to oral challenge using Salmonella enterica serovar Typhimurium (214).”
Multifunctional cationic host defence peptides and their clinical applications (2011, background): “enhanced expression in transgenic mice resulted in increased resistance to bacterial infections [1, 91].”