A component of innate immunity prevents bacterial biofilm development

By Pradeep K. Singh, M. Parsek, E. P. Greenberg, Michael J. Welsh. Nature, 2002

1,071 citations recorded by the source corpus.

Subfields: Endocrinology, Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0538fbe1abe3e800765fb73c96b1cea4c402eeba

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Citations in the corpus

Antimicrobial Peptides (2013, background): “[208], lactoferrin was found to block biofilm formation of P.”
A review of current and emergent biofilm control strategies (2010, background): “The increased biofilm resistance to conventional treatments enhances the need to develop new control strategies (Simões, Bennett, & Rosa, 2009; Singh et al., 2002).”
Innate immunity: an overview. (2004, background): “Lactoferrin alters the motility of certain bacteria, such as Pseudomonas aeruginosa, and their ability to form biofilms (Singh et al., 2002), and may help to cause their elimination.”
The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa (2012, background): “aeruginosa infection model, iron availability and iron chelation via PVD play important roles in infection establishment (5, 180) and the development of chronic infections (141).”
Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants (2003, background): “Evidence has been presented that twitching motility may be stimulated by iron limitation (Singh et al., 2002), and that it may possibly be directed by chemical gradients (Darzins, 1994; Kearns and Shimkets, 1998; Kearns et al.”
Complicated Catheter-Associated Urinary Tract Infections Due to Escherichia coli and Proteus mirabilis (2008, background): “aeruginosa prevents biofilm formation through the stimulation of twitching motility (373).”
Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues (2009, background): “Many bacterial species switch between planktonic growth and the formation of biofilms, thereby displaying increased antibiotic resistance (38), evasion from host immune defenses (39), or the ability to establish chronic infections in humans (40).”
Sociomicrobiology: the connections between quorum sensing and biofilms. (2005, neutral): “Iron limitation has been previously shown to inhibit biofilm development [ 53 ].”
Human Host Defense Peptide LL-37 Prevents Bacterial Biofilm Formation (2008, background): “Increased surface motility would cause bacteria to wander across the surface instead of forming biofilms and is known to result in thin and flat biofilms without the mushroom-like structure (35, 49).”