Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.

By Fabio Martinon, Laetitia Agostini, E. Meylan, J. Tschopp. Current Biology, 2004

628 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0f80adf27bd660ad0e1fba7dbfee851704b7a2cf

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In Molecular Biology

Citations in the corpus

Thioredoxin-interacting protein links oxidative stress to inflammasome activation (2010, neutral): “or pathogen-associated molecular patterns, such as muramyldipeptid”
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “For instance, NALP3 has been ascribed a role in recognition of ATP (226), uric acid crystals (232), viral RNA (168), and bacterial DNA (268), whereas both NALP3 and NALP1 have been demonstrated to mediate caspase-1 activation in response to bacterial MDP (85, 230).”
Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “A critical step in the activation of caspase-1 is the assembly of a large protein complex that includes NLR proteins, the adapter apoptosis-associated speck-like protein containing a C-terminal CARD (ASC) and pro-caspase-1 (142, 143) (Fig.”
Are innate immune signaling pathways in plants and animals conserved? (2005, background): “Like Nod2, NALP3, which is a key component of the 'inflammasome', is activated by the muramyl dipeptide component of peptidoglyca”
Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector? (2015, neutral): “For example, excessive levels of ATP were described as one of the ﬁrst endogenous DAMPs to induce NLRP3 inﬂammasome formation and activation, a mechanism involving high concentrations of extracellular ATP binding to the purinergic P2X7 receptor (104).”
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells (2005, background): “We thank G. Natoli and A. Macagno for critical reading and A. Martı́nFontecha for help with the experiments using mouse DCs. Supported in part by the Swiss National Science Foundation (31-63885), National Institutes of Health (U19AI057266/01) and European Community (Sixth Framework Programme, contra”
Signalling pathways and molecular interactions of NOD1 and NOD2 (2006, background): “This view is underscored by the recent discovery that cryopyrin (also known as NALP3 or CIAS1), an NLR-family member that is structurally similar to NOD2 except that it contains a pyrin domain in place of a CARD, is also activated by MD”
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration (2007, background): “Human NALP1 detects, like NALP3, MDP.5 As caspase-1 activation by PGN/MDP was inhibited by high Kþ , it is likely that NALP1 and NALP3 inflammasomes both require Kþ efflux for activation.”