Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

By Virginie Petrilli, S. Papin, Catherine Dostert, Annick Mayor, Fabio Martinon, J. Tschopp. Cell Death and Differentiation, 2007

1,476 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/2f50bf68df562dc521471dc04ec000243fb14b49

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Tschopp
2. G. Núñez
3. M. Lamkanfi
4. V. Dixit
5. E. Latz
6. Yuan He
7. T. Kanneganti
8. L. Franchi

In Physiology

1. G. Núñez
2. H. Hammad
3. B. Lambrecht
4. Heike Wulff
5. J. Tschopp
6. E. Skolnik
7. M. Lamkanfi
8. V. Dixit

In Public Health, Environmental and Occupational Health

1. J. Tschopp
2. G. Núñez
3. C. A. Dinarello

Citations in the corpus

• Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation (2010, background): “Potassium efflux [32], leakage of lysosomal cathepsin B into the cytoplasm [24], and/or reactive oxygen species formation [14] caused by these substances seem to be essential intermediate steps in activation of NLRP3 receptor, although the interplay between these processes is poorly understood [11,1”
• Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome (2008, background): “Taken together, NALP3 inflammasome activation in vitro by alum requires endocytosis of the particle, K efflux, and generation of ROS, but not release of ATP or uric acid.”
• Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “known to activate the NLRP3 fail to do so if the cells are incubated with buffers rich in K, which prevents the decrease in intracellular K concentrations induced by ATP stimulation or damage of cellular integrity (186, 190, 191).”
• Reactive oxygen species and mitochondria: A nexus of cellular homeostasis (2015, background): “Initial studies focused on NOX2 as the relevant ROS source: inhibition or knockdown of NOX2 were found to block IL-1β secretion in response to NLRP3 stimuli [105,109,131].”
• Initiation and perpetuation of NLRP3 inflammasome activation and assembly (2015, background): “Nearly all NLRP3 agonists induce and require ROS for activation (56, 57, 99, 100).”
• The inflammasomes: guardians of the body. (2009, background): “Assembly can be inhibited by complementing the cell extracts with potassium levels that mimic normal levels found in the cytosol of healthy cells (over 70 mM) (70, 93, 94).”
• The Nalp3 inflammasome is essential for the development of silicosis (2008, background): “The generation of NALP3-, ASC-, caspase-1-, and IPAF-deficient mice has been described previously (12, 27, 28).”