Thioredoxin-interacting protein links oxidative stress to inflammasome activation

By Rongbin Zhou, Aubry Tardivel, B. Thorens, I. Choi, J. Tschopp. Nature Immunology, 2010

2,638 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/876e7682aa7baaacd1124825be5a10dd03794c22

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. C. A. Dinarello
2. G. Núñez
3. T. Kanneganti
4. M. Lamkanfi
5. J. Tschopp
6. V. Dixit
7. Kate Schroder
8. Yuan He

In Physiology

1. C. A. Dinarello
2. Kate Schroder
3. G. Núñez
4. J. Tschopp
5. A. Chawla
6. S. Reddy
7. Khiem A. Tran
8. M. Lamkanfi

Citations in the corpus

• Activation of the Nlrp3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes (2010, background): “TXNIP is not involved in IAPP activation of IL-1β The thioredoxin-interacting protein TXNIP has been identified as a redox-sensitive ligand of NLRP3 (ref”
• The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity (2010, background): “Interestingly, hyperglycemic conditions have been shown to activate NLRP3 in pancreatic cells, and a similar mechanism may exist in adipose tissue (Zhou et al., 2010).”
• Role of nrf2 in oxidative stress and toxicity. (2013, background): “ROS oxidize Trx active site cysteine thiols, causing dissociation of TXNIP from Trx; freed TXNIP binds to NLRP3 to induce robust activation of the inflammasome (25) (Figures 1b and 3b).”
• The inflammasome: an integrated view (2011, background): “It was recently shown that the thioredoxin-interacting protein (TXNIP) is a ROS-sensitive regulator of NLRP3 inflammasome activation (114).”
• Reactive oxygen species and mitochondria: A nexus of cellular homeostasis (2015, background): “Co-precipitation experiments indicate an interaction between TXNIP and NLRP3 [149,150], and immunostaining showed an ROS-dependent recruitment of TXNIP and NLRP3 to mitochondria and or mitochondria-associated membranes in a subsequent study [45].”
• Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders (2017, background): “In contrast to other sensor proteins, NLRP3 can sense many different factors derived from not only pathogen but also environment or host, so the aberrant activation of the NLRP3 inflammasome has been regarded as an important initiator or promoter in a variety of human complex diseases, including typ”
• Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. (2014, background): “islet inflammation induced by chronic exposure to high levels of free fatty acids and glucose, leading to increased apoptosis and impaired insulin secretion of β-cells [49, 52, 53].”
• Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes (2012, methodology): “Key mechanisms of hyperglycemia-induced inflammation include nuclear factor-kB–dependent production of proinflammatory cytokines, Toll-like receptor (TLR) expression, increased oxidative stress, and inflammasome activation (4,5).”