Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

By K. Atarashi, Takeshi Tanoue, K. Oshima, W. Suda, Yuji Nagano, H. Nishikawa, S. Fukuda, Takuro Saito, S. Narushima, K. Hase and 12 more. Nature, 2013

2,675 citations recorded by the source corpus.

Subfields: Epidemiology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0f52a617e56fc0b0795aadfacb0fe8e25aead0f3

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Citations in the corpus

Defining dysbiosis and its influence on host immunity and disease (2014, background): “These data suggest that a greater diversity of organisms, even within the same family, can maximally induce host cellular development (Atarashi et al., 2011; 2013).”
Small Molecules from the Human Microbiota (2015, positive): “This activity was further correlated with SCFAs produced by this anti-inflammatory cocktail of bacteria (135, 136).”
Probiotics, gut microbiota, and their influence on host health and disease (2017, background): “Induction of the Treg response has also been observed in some members of the Clostridium clusters IV, XIVa, and XVIII, where some of the strains are claimed to be emerging probiotics [63].”
Diet, metabolites, and "western-lifestyle" inflammatory diseases. (2014, positive): “colonized germ-free mice with human fecal samples and then applied a sequential methodology to identify bacterial species capable of inducing Treg cells (Atarashi et al., 2013).”
Commensal bacteria protect against food allergen sensitization (2014, background): “Increased bacteriainduced luminal IgA and decreased systemic allergen-specific Ig in Clostridia-colonized mice may both be related to reduced systemic allergen uptake.”
The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “The environment of the gut dictates both the composition and functional productivity of the adult gut microbiota, which may interact with the host through presentation of various ligands such as pathogen-associated molecular patterns (PAMPs) and production of metabolites, e.g., SCFAs.”
Antibiotic-Induced Changes in the Intestinal Microbiota and Disease. (2016, background): “A follow up study described a protective consortium of 17 clostridia strains isolated from a human fecal sample, a community with therapeutic potential for allergic or inflammatory diseases such as colitis [37].”
Role of the Microbiota in Immunity and inflammation (2014, background): “Clostridia, has been shown to directly induce colonic Tregs that can oppose colitis induction (Atarashi et al., 2013; Atarashi et al., 2011).”