Diet, metabolites, and "western-lifestyle" inflammatory diseases.

By A. Thorburn, L. Macia, C. Mackay. Immunity, 2014

827 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/179b2b0bc0646b7ad35ee17e129004a9541b8fae

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In Genetics

1. Mihai G. Netea
2. Luigi Fontana
3. Beatrice Bertozzi
4. Valeria Tosti

In Molecular Biology

1. Joachim L. Schultze
2. Luigi Fontana
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Citations in the corpus

• Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases (2019, background): “In colonocytes (5), butyrate is β-oxidized to Acetyl-CoA and constitutes”
• Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming (2018, background): “Alterations in diets can have deleterious effects on immune responses and drive the development of a range of inflammatory diseases (Thorburn et al., 2014).”
• Microbes, metabolites, and the gut–lung axis (2019, background): “Signaling through these transmembrane receptors linked to regular G proteins is associated with an inflammatory effect through activation of mitogen-activated protein (MAP) kinases, phosphoinositide 3 (PI3K)-kinases, and mammalian target of rapamycin (mTOR).(82) Alternatively, signal transduction pa”
• Gut Microbiome: Profound Implications for Diet and Disease (2019, background): “By influencing metabolism and inflammation, diet and nutrition can outweigh genetic and environmental factors in determining health outcomes for chronic Western conditions such as diabetes, obesity, IBS, IBD, colorectal cancer, and depression [1,2,318].”
• Promoting Health and Longevity through Diet: from Model Organisms to Humans (2015, neutral): “G-protein-coupled receptors expressed by enteroendocrine and immune cells may be important mediators of the effects of the microbiome (Thorburn et al., 2014).”
• Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism (2018, background): “Recent studies have emphasized the profound effects of diet and nutrients on the localization and composition of the gutmicrobiota as well as on the connection between the gut microbiota and immunological pathways (Thorburn et al., 2014).”
• Microbiota metabolite short chain fatty acids, GCPR, and inflammatory bowel diseases (2016, background): “SCFA might activate NALP6 through the GPCR pathway, further promoting gut goblet cells to secret mucus, which is an important barrier to separate the bacteria and epithelial cells [53, 54].”
• Influence of maternal obesity on the long-term health of offspring (2016, neutral): “39 There is preliminary evidence in humans that dietary manipulation of the maternal microbiome in pregnancy with prebiotic fibre has beneficial effects for both offspring immune function and metabolism (reviewed in [40]).”