The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

By Yue Zhao, Jieling Yang, Jianjin Shi, Yi-Nan Gong, Qiuhe Lu, Hao Xu, Liping Liu, F. Shao. Nature, 2011

1,238 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/0ec72dc8060e1a065d7d0da120a943810ea9a784

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. K. Honda
2. Edward A. Miao
3. M. Lamkanfi
4. F. Shao
5. Dan R. Littman
6. Jeffery L. Dangl
7. V. Dixit
8. R. Vance

In Molecular Biology

1. Edward A. Miao
2. M. Lamkanfi
3. V. Dixit
4. F. Shao
5. Ine Jorgensen
6. Jingjin Ding
7. K. Honda
8. Kun Wang

Citations in the corpus

• Inflammasomes and their roles in health and disease. (2012, background): “Instead, human NAIP activates the NLRC4 inflammasome upon detection of Chromobacterium violaceum CprI and homologous needle subunits of the type III secretion apparatus of S. typhimurium, B. thailandensis, P. aeruginosa, and S. flexneri (Zhao et al. 2011).”
• Mechanisms of Action of Adjuvants (2013, background): “Apart from danger signals, inflammasomes can be activated by PAMPs such as bacterial flagellin through NLRC4 activation (Zhao et al., 2011).”
• The Microbiome in Infectious Disease and Inflammation (2012, positive): “TLR9-deficient mice have decreased numbers of LP Th17 cells (153), and in vitro differentiation of intestinal Th17 cells is enhanced by the addition of flagellin, a ligand for TLR5 (76) and NLRC4 inflammasomes (154, 155).”