Polymeric system for dual growth factor delivery

By T. P. Richardson, M. Peters, Alessandra B. Ennett, David J. Mooney. Nature Biotechnology, 2001

1,759 citations recorded by the source corpus.

Subfields: Biomaterials, Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0de59f911f1eb6cd937042aea6507f5f4fb9f8bb

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Citations in the corpus

Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering (2005, background): “As many cellular processes involved in morphogenesis require a complex network of several signaling pathways and usually more than one growth factor, recent research efforts have focused on schemes for sequential delivery of multiple growth factor”
Three-Dimensional Cell Culture Matrices: State of the Art (2008, methodology): “The gas-foaming process is favorable for incorporating biological molecules because no organic solvent is used.(76) Solvent casting and particulate leaching are representative methods of achieving a sponge-like porous matrix with a porogen.”
Molecular regulation of vessel maturation (2003, background): “Delivery of VEGF and PDGF in combination using a controlled-release polymeric device leads to vessels that appear more mature than those formed using VEGF alon”
Controlled drug delivery in tissue engineering. (2008, background): “Some relevant results have been achieved by the group of Mooney [17], who developed PLGA scaffolds for the sequential release of multiple GFs by mixing free VEGF with empty and PDGF-loaded polymer particles and subsequently assembling them into a porous scaffold [140].”
PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine (2008, neutral): “factors to promote vascularization (90) to increasingly sophisticated strategies to present survival or differentiation cues for stem/progenitor cell differentiation (91–93).”
Building drug delivery into tissue engineering design (2002, background): “Systems that release multiple protein factors are also possibl”
Stem Cell Organoid Engineering (2016, neutral): “…functionalized with a combination of proangiogenic biomolecules, such as vascular endothelial growth factors (VEGFs), platelet-derived growth factors (PDGGFs), and basic fibroblast growth factors (BFGFs) for rapid formation of mature vascular networks (Richardson et al., 2001; Zisch et al., 2003).”