Controlled drug delivery in tissue engineering.

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Bone tissue engineering: A review in bone biomimetics and drug delivery strategies (2009, background): “Therefore, many of the strategies investigated (such as bolus administration) is not effective due to rapid diffusion from the target site and deactivation/digestion by ubiquitous enzymes.(228) Ideally, the presentation of bioactive molecules or drugs must be finely tuned to dynamically match the ph”
A review of bacterial cellulose‐based drug delivery systems: their biochemistry, current approaches and future prospects (2014, background): “For example, therapeutic proteins such as growth factors and signalling molecules have both been delivered in this way.([104]) BC is an excellent candidate for TES as evidenced by the results of a study in which BC nanofibres with appropriate porosity were investigated for their application as bioco”
Drug Release Kinetics and Transport Mechanisms of Non-degradable and Degradable Polymeric Delivery Systems (2010, background): “PEVA-based devices are designed to release drug compounds slowly over a relatively long period of time [27].”