Stem Cell Organoid Engineering
By Xiaolei Yin, Benjamin E. Mead, Helia Safaee, Robert Langer, J. Karp, O. Levy. Cell Stem Cell, 2016
738 citations recorded by the source corpus.
Organoid systems leverage the self-organizing properties of stem cells to create diverse multi-cellular tissue proxies. Most organoid models only represent single or partial components of a tissue, and it is often difficult to control the cell type, organization, and cell-cell/cell-matrix interactions within these systems. Herein, we discuss basic approaches to generate stem cell-based organoids, their advantages and limitations, and how bioengineering strategies can be used to steer the cell composition and their 3D organization within organoids to further enhance their utility in research and therapies.
Subfields: Biomedical Engineering, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/55f1864597c53d634f47d51cd2f66078beceff7c
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In Biomedical Engineering
In Oncology
Citations in the corpus
- Is It Time to Start Transitioning From 2D to 3D Cell Culture? (2020, background): “Organoids aggregate into spheroids by forming ECM fibers that link single cells together via integrin binding and mimic the microenvironment of certain organs to allow researchers to model human diseases through the use of patientderived pluripotent stem cells (Yin et al., 2016).”
- Brain Region-specific Organoids using Mini-bioreactors for Modeling ZIKV Exposure (2016, neutral): “Structures resembling whole developing organs, named organoids, have recently been generated via 3D cultures and include intestinal, kidney, retinal, and cerebral organoids (Lancaster and Knoblich, 2014; Yin et al., 2016).”