PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine

By Chien-Chi Lin, K. Anseth. Pharmaceutical Research, 2008

993 citations recorded by the source corpus.

Polyethylene glycol (PEG) hydrogels are widely used in a variety of biomedical applications, including matrices for controlled release of biomolecules and scaffolds for regenerative medicine. The design, fabrication, and characterization of PEG hydrogels rely on the understanding of fundamental gelation kinetics as well as the purpose of the application. This review article will focus on different polymerization mechanisms of PEG-based hydrogels and the importance of these biocompatible hydrogels in regenerative medicine applications. Furthermore, the design criteria that are important in maintaining the availability and stability of the biomolecules as well as the mechanisms for loading of biomolecules within PEG hydrogels will also be discussed. Finally, we overview and provide a perspective on some of the emerging novel design and applications of PEG hydrogel systems, including the spatiotemporal-controlled delivery of biomolecules, hybrid hydrogels, and PEG hydrogels designed for controlled stem cell differentiation.

Subfields: Biomedical Engineering, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/dd81e025b161b507e86c7beeb3637594cb6ee93e

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Citations in the corpus

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A practical guide to hydrogels for cell culture (2016, background): “…of different functional groups, and hydrogels can be formed using a variety of chain-growth, step-growth, or mixed-mode polymerization techniques 13 , giving the user more studies including the investigation of cell migration in microfluidic hydrogels 85 and high-throughput screening platforms…”
Designing materials to direct stem-cell fate (2009, background): “For example, PEG-based hydrogels have been rendered chemically degradable through hydrolytic breakdown of ester bond”