Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity

By O. Gross, A. Gewies, Katrin Finger, M. Schäfer, T. Sparwasser, C. Peschel, I. Förster, J. Ruland. Nature, 2006

888 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/0d9bb739b5cbe2bb819ae80ee5b17006e7d6aa73

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Citations in the corpus

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17 (2007, background): “This allows recruitment of the spleen tyrosine kinase Syk, which then activates 'downstream' signaling components, including the transcription factor NF-κ”
The effects of β-glucan on human immune and cancer cells (2009, background): “They are NF-κB (through Syk-mediate pathway), signaling adaptor protein CARD9 and nuclear factor of activated T cells (NFAT) [39-41] (Fig.”
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome (2012, background): “In particular, the C-type lectin dectin-1 has emerged as an important participant in fungal recognition by DCs and in the induction of protective T helper type 1 (T H 1) and T H 17 immune response”
Mincle is an ITAM-coupled activating receptor that senses damaged cells (2008, background): “The adaptor molecule CARD9 has been shown to be essential in linking Syk to inflammatory response”
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. (2011, background): “CARD9 was originally identified as an essential molecule involved in antifungal immunity (Gross et al., 2006).”
Candida albicans morphogenesis and host defence: discriminating invasion from colonization (2011, positive): “The important role of dectin 1 and CARD9 in antifungal host defence has been confirmed by in vivo studie”
Neutrophil cell surface receptors and their intracellular signal transduction pathways (2013, background): “Based on studies on other Syk-coupled receptors and other cell types, it is expected that SLP-76, PLCγ2, the CARD9 adapter, NF-κB-mediated gene transcription and the NLRP3 inflammasome are also involved in signaling by C-type lectins [61,217,218].”
Signalling through C-type lectin receptors: shaping immune responses (2009, background): “specifically, dectin 1 activates gene expression through the recognition of β-1,3-glucan PAMPs expressed by a broad range of fungal pathogens, including C. albicans, Aspergillus fumigatus and Pneumocystis carinii, which then leads to the activation of NF-κB 4, 17, 42, 43 (fIG.”