Wound healing essentials: Let there be oxygen
By Chandan K. Sen. Wound Repair and Regeneration, 2009
625 citations recorded by the source corpus.
The state of wound oxygenation is a key determinant of healing outcomes. From a diagnostic standpoint, measurements of wound oxygenation are commonly used to guide treatment planning such as amputation decision. In preventive applications, optimizing wound perfusion and providing supplemental O2 in the perioperative period reduces the incidence of postoperative infections. Correction of wound pO2 may, by itself, trigger some healing responses. Importantly, approaches to correct wound pO2 favorably influence outcomes of other therapies such as responsiveness to growth factors and acceptance of grafts. Chronic ischemic wounds are essentially hypoxic. Primarily based on the tumor literature, hypoxia is generally viewed as being angiogenic. This is true with the condition that hypoxia be acute and mild to modest in magnitude. Extreme near‐anoxic hypoxia, as commonly noted in problem wounds, is not compatible with tissue repair. Adequate wound tissue oxygenation is required but may not be sufficient to favorably influence healing outcomes. Success in wound care may be improved by a personalized health care approach. The key lies in our ability to specifically identify the key limitations of a given wound and in developing a multifaceted strategy to specifically address those limitations. In considering approaches to oxygenate the wound tissue it is important to recognize that both too little as well as too much may impede the healing process. Oxygen dosing based on the specific need of a wound therefore seems prudent. Therapeutic approaches targeting the oxygen sensing and redox signaling pathways are promising.
Subfields: Endocrinology, Diabetes and Metabolism, Pathology and Forensic Medicine, Rehabilitation
View Paper: https://www.semanticscholar.org/paper/6adbe983882ad4a6afe2ab5620f9a7841a8e4e3a
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Citations in the corpus
- Inflammation and wound healing: The role of the macrophage (2011, neutral): “Thrombosis and Haemostasis 105, 811-819 56 Sen, C.K. et al. (2009) Human skin wounds: a major and snowballing threat to public health and the economy.WoundRepairandRegeneration17,763-771 57 Browder, W. et al. (1988) Effect of enhanced macrophage function on early wound healing. Surgery 104, 224-230 ”
- Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS‐modulating technologies for augmentation of the healing process (2017, background): “This may deplete O2 levels to an extent that ROS mediate responses are affected as its generation relies on O2 presence (29).”