What does Stat3 do?

By D. Levy, Chien-Kuo Lee. Journal of Clinical Investigation, 2002

916 citations recorded by the source corpus.

Subfields: Oncology, Pathology and Forensic Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/0bf9fe9b084617c4a7d43266e7fb3c613139b1c0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. J. O’Shea
2. A. Laurence
3. Y. Kanno
4. Jacqueline F. Bromberg
5. R. Taub

In Pathology and Forensic Medicine

1. F. Powrie
2. Jacqueline F. Bromberg
3. R. Taub

In Pharmacology

1. Jacqueline F. Bromberg
2. J. O’Shea
3. R. Taub

Citations in the corpus

• STAT proteins: From normal control of cellular events to tumorigenesis (2003, background): “Since, compared to the other members of their family, STAT1, STAT5, and even more, STAT3, play a great many roles in several cell contexts, they would seem to have more importance than the others in the pathogenesis of different tumors, as we will see below (Levy and Lee, 2002).”
• Liver regeneration: from myth to mechanism (2004, background): “What distinguishes them from growth factors is their ability to activate selective intracellular-signalling pathways that are not linked to MITOGENESIS”
• Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis (2010, background): “Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that serves critical functions in development, cell growth, and homeostasis in a variety of tissues (Hirano et al., 2000; Levy and Lee, 2002).”
• Stat proteins and oncogenesis. (2002, background): “As discussed by Levy and Lee in this series (6), Stat3 is implicated in keratinocyte migration, T cell apoptosis, IL-10–mediated signaling in macrophages, and the induction of apoptosis in the involuting breast.”
• The STAT3 isoforms α and β have unique and specific functions (2004, background): “One of the peculiar characteristics of STAT3 is its capacity to activate different sets of genes in different cell type”
• The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation (2007, background): “Indeed, STAT3 is generally recognized as an anti-inflammatory transcription factor (Takeda et al., 1999; Levy and Lee, 2002) contributing to the anti-inflammatory effects of IL-6 and IL-10 (Takeda et al.”
• Signalling: STATs: transcriptional control and biological impact (2002, neutral): “The phenotypes resulting from the loss of Stat3 in adult tissues include failure of cell survival, impaired apoptosis, loss of negative feedback regulation and impaired cell migration and wound healin”