Stat proteins and oncogenesis.
By Jacqueline F. Bromberg. Journal of Clinical Investigation, 2002
896 citations recorded by the source corpus.
Subfields: Cancer Research, Epidemiology, Oncology
View Paper: https://www.semanticscholar.org/paper/348b2037b9803698fe73b92dcf9bd185f04e080a
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Citations in the corpus
- G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes (2005, background): “To investigate the molecular mechanism of how G-CSF exerts an antiapoptotic effect on cultured cardiomyocytes, we examined expression of the Bcl-2 protein family, known target molecules of the Jak-Stat pathwa”
- What does Stat3 do? (2002, background): “The finding, discussed in detail by Bromberg in this Perspective series (25), that Stat3 may be a key player in the pathogenesis of diverse human cancers makes this molecule a prime target for novel therapies and lends greater urgency to answering this complex question.”
- Drosophila orthologues to human disease genes: an update on progress. (2008, background): “In humans, hyperactivation of STAT homologues is associated with various leukemias and lymphomas (152, 153).”
- Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. (2007, background): “STAT3 is transiently activated in normal cells but constitutively activated in a wide variety of hematologic and epithelial primary tumors and tumor-derived cell lines, such as leukemias; lymphomas; head and neck, prostate, ovarian, breast, and renal cell cancers; and melanoma (12, 13).”
- Myeloid-derived-suppressor cells as regulators of the immune system (2009, neutral): “2 ), which are signalling molecules that are involved in cell survival, proliferation, differentiation and apoptosi”
- STAT proteins: From normal control of cellular events to tumorigenesis (2003, background): “…and solid neoplasias (head and neck, brain, breast, lung, pancreas, prostate cancers) (Catlett-Falcone et al., 1999; Bowman et al., 2000; Coffer et al., 2000; Huang et al., 2000; Lin et al., 2000; Song and Grandis, 2000; Garcia et al., 2001; Bromberg, 2002; Schaefer et al., 2002) (Table 1).”
- Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. (2006, background): “It is constitutively activated by aberrant upstream tyrosine kinase activities in a broad spectrum of cancer cell lines and human tumors [8, 9].”