A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans.
By D. Cummings, J. Purnell, R. S. Frayo, Karin Schmidova, Brent E. Wisse, D. Weigle. Diabetes, 2001
3,046 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology
View Paper: https://www.semanticscholar.org/paper/0b2f96567a14362f0001b6969e11b56d54fb4251
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In Endocrine and Autonomic Systems
In Nutrition and Dietetics
In Physiology
Citations in the corpus
- Ghrelin: structure and function. (2005, background): “Plasma ghrelin concentration is increased in fasting conditions and reduced after habitual feeding (50, 247), suggesting that ghrelin may be as an initiation signal for food intake or ghrelin secretion is controlled by some nutritional factors in blood.”
- A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. (2005, methodology): “Ghrelin concentrations in these pools were measured in duplicate in 2 separate assays that were normalized to one another by using internal controls as described previously (15).”
- The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review (2007, background): “Ghrelin levels show preprandial increases and postprandial decreases (59,97,98).”
- High-fat diet-induced obesity in animal models (2010, background): “Ghrelin rises before and falls after each ad libitum meal and increases food intake (190,191) .”
- Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index (2004, positive): “Additionally, studies have shown a high correlation between morning, fasting leptin and ghrelin levels and 24-h mean profile [29,30].”
- AMPK - a nutrient and energy sensor that maintains energy homeostasis (2012, neutral): “This model is consistent with observed diurnal patterns of plasma ghrelin and leptin in humans eating normal meal”
- Ghrelin controls hippocampal spine synapse density and memory performance (2006, background): “Thus, the major emphasis of ghrelin research has been on possible roles for ghrelin in meal initiatio”
- Weight Loss, Appetite Suppression, and Changes in Fasting and Postprandial Ghrelin and Peptide-YY Levels After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: A Prospective, Double Blind Study (2008, background): “Ghrelin has been proposed to have a role in meal initiation as the levels rise preprandially and fall proportionately in response to calorie ingestion.(11) Circulating ghrelin levels are decreased in human obesity.”
- Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. (2004, background): “(202, 209) indicates that each daily meal is followed by decreases of circulating ghrelin levels, most likely reflecting acutely reduced ghrelin secretion from the gastrointestinal tract.”
- Inhibition of food intake in obese subjects by peptide YY3-36. (2003, neutral): “Gut hormone PYY(3-36) physiologically inhibits food intake.”
- Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. (2008, neutral): “Interest in ghrelin rose dramatically when it was demonstrated that ghrelin concentrations in human plasma rise immediately before mealtimes (Cummings et al., 2001; Cummings, 2006).”