Inhibition of food intake in obese subjects by peptide YY3-36.

By R. Batterham, Mark A Cohen, S. Ellis, C. le Roux, D. Withers, G. Frost, M. Ghatei, Stephen R. Bloom. New England Journal of Medicine, 2003

1,665 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0c4518729cf022291631d171994ac340247ddfde

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. K. Murphy
2. Stephen R. Bloom

In Molecular Biology

1. T. Preston
2. G. Gibson
3. D. Morrison
4. J. F. Mota
5. Christian Hoffmann
6. A. Gomes

Citations in the corpus

• Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index (2004, neutral): “appetite regulatory hormones, such as PYY 3–36 [28], were not measured.”
• Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults (2014, methodology): “25 27 In this study, the rise in PYY and GLP-1 was apparent between 240 min and 420 min following oral administration of the inulin-propionate ester, and reached levels similar to those observed following a 1000 kcal meal.”
• The human gut microbiota: Metabolism and perspective in obesity (2018, result): “Batterham et al.(73) found a 30% reduction in food intake 90 minutes after the infusion of PYY3–36 in obese individuals, a value similar to eutrophic patients.”
• Neuroendocrine control of food intake. (2008, background): “Notably, the reduction of caloric intake observed in obese patients following infusion of PYY3e36 is accompanied by a decrease in circulating ghrelin [25].”
• Gut hormones and the regulation of energy homeostasis (2006, background): “Obese humans show normal sensitivity to the anorectic effects of PYY 3–36 , and circulating levels of PYY are not raised in the obese, in contrast to leptin level”
• Gut Hormone Profiles Following Bariatric Surgery Favor an Anorectic State, Facilitate Weight Loss, and Improve Metabolic Parameters (2006, background): “Following RYGB, postprandial PYY concentrations were elevated to levels previously shown to have appetite-reducing effects.(19,20) We propose that the higher postprandial PYY response after gastric bypass surgery due to the altered intestinal anatomy may contribute to the patients’ increased satiety”
• Weight Loss, Appetite Suppression, and Changes in Fasting and Postprandial Ghrelin and Peptide-YY Levels After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: A Prospective, Double Blind Study (2008, background): “Intravenous infusion of PYY3–36 in humans induces satiety and reduces food intake.(19,20) Recent studies have shown depressed PYY levels in morbidly obese individuals in comparison to lean controls and blunted response in PYY release after meal stimulation.”