Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.

By Jing Yang, Michael S. Brown, G. Liang, Nick V. Grishin, J. Goldstein. Cell, 2008

1,178 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/e832d12fd01fdfb32f3d8cb1d6c1ce031fc7a0cc

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In Endocrine and Autonomic Systems

1. D. Virshup

Citations in the corpus

• Precise Regulation of Porcupine Activity Is Required for Physiological Wnt Signaling (2012, background): “In the MBOAT protein ghrelin O-acyltransferase, which transfers octanoate onto the appetite-stimulating hormone ghrelin, the asparagine and histidine equivalent to PORCN Asn-306 and His-341 are absolutely required for enzyme activity (42).”
• Structure, mechanism, and inhibition of Hedgehog acyltransferase (2021, background): “PORCN catalyzes O-palmitoleoylation of Wnt in development (Herr and Basler, 2012), while GOAT catalyzes ghrelin O-octanoylation in appetite regulation (Gutierrez et al., 2008; Yang et al., 2008).”
• Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer (2009, background): “As other important signaling molecules frequently associated with disease, such as the Hedgehog proteins and the appetite-regulating hormone ghrelin, are also substrates of MBOAT family member”