Ghrelin controls hippocampal spine synapse density and memory performance

By S. Diano, S. Farr, S. Benoit, E. McNay, I.D.C. Guerreiro da Silva, B. Horvath, F. Gaskin, N. Nonaka, Laura B. Jaeger, William A. Banks and 8 more. Nature Neuroscience, 2006

838 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/ed71645a1b530393f2d3862ed437ab76250f7ac4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. K. Murphy
2. Stephen R. Bloom

In Nutrition and Dietetics

1. K. Murphy
2. G. Shadel
3. Stephen R. Bloom

In Physiology

1. G. Shadel
2. T. Horvath

Citations in the corpus

• The Influence of Exercise on Cognitive Abilities (2013, neutral): “Ghrelin is secreted from an empty stomach and can bind hippocampal receptors with profound effects on hippocampal synaptic plasticity, altering LTP, and hippocampal-dependent learning and memory (46,119).”
• Visceral influences on brain and behavior. (2013, neutral): “Ghrelin modulates hippocampal synapse density (Diano et al., 2006) and a high-fat meal is associated with spatial memory impairment within 72 hr (Kanoski and Davidson, 2010).”
• Brain foods: the effects of nutrients on brain function (2008, neutral): “, and in the hippocampus it promotes synapse formation in dendritic spines and LTP, which are paralleled by enhanced spatial learning and memory formatio”
• Mitochondrial ROS signaling in organismal homeostasis. (2015, background): “Similar ghrelin action was also found in the hippocampus to promote learning and memory and to ameliorate deficits of animals in a model of Alzheimer’s disease (Diano et al., 2006).”
• Gut hormones and the regulation of energy homeostasis (2006, background): “Peptide YY and the Y2 agonist PYY-(13-36) inhibit neurons of the dorsal motor nucleus of the vagus.”