Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation
By E. Drenkard, Frederick M. Ausubel. Nature, 2002
1,040 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/0a90d36c39f7dac4db0bb02dd74ca91d2035e774
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Citations in the corpus
- Rhamnolipid Surfactant Production Affects Biofilm Architecture in Pseudomonas aeruginosa PAO1 (2003, background): “aeruginosa mutants, including those deficient in flagellum and pilus synthesis, as well as those with mutations in global regulators such as gacA and crc, have defects in the initial colonization of a surface (9, 22, 24, 27).”
- Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow (2010, background): “or promote virulence and biofilm formation have been documente”
- Combination Therapy for Treatment of Infections with Gram-Negative Bacteria (2012, background): “Bacteria growing in biofilms are generally significantly more resistant, and biofilms often coat the airways of patients with cystic fibrosis (2, 61, 176, 229) Lastly, synergy testing is performed on the sickest patients with highly resistant organisms who have a very poor prognosis, and synergistic”
- Human Host Defense Peptide LL-37 Prevents Bacterial Biofilm Formation (2008, background): “Once established, these sessile communities constitute a protected mode of growth that promotes survival in a hostile environment and are difficult to treat due to their high inherent resistance to antimicrobial agents (12, 14, 50).”
- Natural functions of lipopeptides from Bacillus and Pseudomonas: more than surfactants and antibiotics. (2010, background): “The extracellular matrix of the biofilm protects bacteria against adverse environmental conditions: for example, biofilms are less susceptible to antibiotic treatment or shearing (Drenkard & Ausubel, 2002; Hall-Stoodley et al ., 2004).”
- Pseudomonas aeruginosa population structure revisited under environmental focus (2010, background): “Possible explanation of physiological changes might be associated with the adaptation processes allowing bacteria to survive in the hostile surrounding of the lungs of CF patients (Drenkard & Ausubel, 2002; Mahenthiralingam et al., 1994; Mahenthiralingam & Speert, 1995).”
- Pathophysiology and management of pulmonary infections in cystic fibrosis. (2003, background): “aeruginosa in microcolonies has been proposed for many years (131), support for the existence of biofilms in CF has recently been reported (132, 133).”
- Extracellular DNA Chelates Cations and Induces Antibiotic Resistance in Pseudomonas aeruginosa Biofilms (2008, background): “aeruginosa are additional examples of regulators of biofilm formation [41].”
- Specialized Persister Cells and the Mechanism of Multidrug Tolerance in Escherichia coli (2004, background): “So far, studies aimed at identifying genes responsible for biofilm resistance were limited to the bulk of the population (33), which is fairly susceptible to therapeutic doses of antibiotics or may express resistance genes that act equally well in exponentially growing cells (9, 18).”
- Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media. (2006, background): “Other evidence suggests that biofilm bacteria may have genetic mechanisms, selected for in the biofilm, that provide antimicrobial protection.(29-31) In addition, the biofilm provides a physical barrier that enhances pathogen resistance to host defenses such as opsonization, lysis by complement, and”