Pathophysiology and management of pulmonary infections in cystic fibrosis.

By R. Gibson, J. Burns, B. Ramsey. American Journal of Respiratory and Critical Care Medicine, 2003

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The multifarious, multireplicon Burkholderia cepacia complex (2005, background): “Bcc transmission is thought to occur by aerosol droplet and direct physical contact with infected individuals or contaminated surfaces, and control strategies are aimed at these routes of sprea”
The role of bacterial biofilms in chronic infections (2013, background): “, recurrent or chronic bacterial lung infections (255, 261) (see Fig.”
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770 (2009, positive): “The resulting dehydration of the airway surface is believed to contribute to the deleterious cascade of mucus accumulation, infection, inflammation and destruction that characterizes CF lung disease (12).”
The Changing Microbial Epidemiology in Cystic Fibrosis (2010, background): “CF is caused by mutations in the CF transmembrane conductance regulator (CFTR) protein, which normally functions to regulate the transepithelial ion flow critical to maintaining the proper ionic composition and volume of airway surface fluid (105).”
Practice parameter for the diagnosis and management of primary immunodeficiency. (2015, background): “(D) Allergic inflammation can predispose patients to frequent bacterial infections, such as otitis media and sinusitis.(18,19) Adenoid hypertrophy can also be associated with frequent ear and sinus infections.”