Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media.

By L. Hall-Stoodley, F. Hu, A. Gieseke, L. Nistico, Duc Nguyen, J. Hayes, Michael L. Forbes, D. Greenberg, Bethany Dice, Amy C. Burrows and 5 more. Journal of the American Medical Association (JAMA), 2006

887 citations recorded by the source corpus.

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Citations in the corpus

The biology and future prospects of antivirulence therapies (2008, background): “Clinical studies of recurrent infection of the middle-ear tissue in children indicate that chronic otitis media stems from a persistent biofilm following the first infectio”
Evolving concepts in biofilm infections (2009, methodology): “Detection of bacteria by culture methods was positive for OM pathogens in children undergoing tympanostomy tube (TT) placement less than 30% of the time, compared with polymerase chain reaction (PCR) and FISH which were positive ~80–90% of the time (Hall-Stoodley et al., 2006).”
The role of bacterial biofilms in chronic infections (2013, methodology): “(218) VIII Implant associated Electron microscopy FISH Marrie et al.”
ESCMID guideline for the diagnosis and treatment of biofilm infections 2014. (2015, unknown): “Soft tissue fillers FISH ~5–25 μm [20] Otitis media FISH ~15–25 μm [200] FISH ~10–80 μm [201] FISH ~4–40 μm [202] Implant-associated Electron microscopy ~500 μm [203] FISH ~50 μm [204] Electron microscopy ~5–15 μm [205] FISH ~5–30 μm [206] Catheter- and shunt-associated Electron microscopy ~5–1000 μ”
Antibiotic resistance of bacterial biofilms. (2010, background): “on natural surfaces such as teeth (3), heart valves (endocarditis), (4) in the lungs of 70 cystic fibrosis (CF) patients causing chronic bronchopneumonia (2), in the middle ear 71 in patients with persistent otitis media (5), in chronic rhinosinusitis (6), in chronic 72 osteomyelitis and prostetic j”
Healthcare-associated infections, medical devices and biofilms: risk, tolerance and control. (2015, background): “For example, in otitis media with effusion, pathogens are identified around 25–30 % of the time by culture methods and 80–100 % of the time by cultureindependent molecular methods (Hall-Stoodley et al., 2006).”
Bacterial Biofilm and its Role in the Pathogenesis of Disease (2020, background): “In patients with recurrent OM (ROM), defined as three or more episodes in 6 months, biofilm was observed in 17 out of 20 children (21 out of 25 ears examined) in biopsies taken during undergoing tympanostomy tube placement [19].”