Links between signal transduction, transcription and adhesion in epithelial bud development

By C. Jamora, R. Dasgupta, Paweł Kocieniewski, Elaine Fuchs. Nature, 2003

595 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0a4c833f5eb14834279df3dd6752923b5f4b0085

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Elaine Fuchs
2. C. Blanpain
3. R. Nusse
4. Linheng Li
5. T. Xie
6. David M. Gonzalez
7. Irving L. Weissman
8. D. Medici

In Molecular Biology

1. Elaine Fuchs
2. C. Blanpain
3. Linheng Li
4. R. Nusse
5. M. Clarke
6. Irving L. Weissman
7. T. Xie
8. M. Wicha

Citations in the corpus

• Signaling mechanisms of the epithelial-mesenchymal transition (2014, background): “LEF-1 is another key transcription factor that can directly induce EMT through its repression of E-cadherin (55).”
• Epidermal stem cells of the skin. (2006, background): “In a process bearing a certain resemblance to the formation of the neural tube, placode formation is dependent on Noggin, a soluble inhibitor of Bmp signaling (Botchkarev et al. 1999, Jamora et al. 2003).”
• Stem cell niche: structure and function. (2005, background): “These observations also support the theory that coordination between Wnt and Noggin (through temporarily overriding the BMP restriction on stem cells) is required to initiate each hair growth cycle (Jamora et al. 2003 and J. Zhang & L. Li, unpublished data).”
• The Wnt signaling pathway in development and disease. (2004, background): “A recent study in the skin (Jamora et al. 2003) has raised the intriguing possibility that Wnt signaling might also generally regulate cell adhesion, although this must be tested further.”
• β-Catenin signaling is required for neural differentiation of embryonic stem cells (2004, background): “Interestingly, it has been shown that inhibition of BMP signaling in epithelial bud development results in the upregulation of Lef1 and an increase in β-catenin signaling (Jamora et al., 2003).”
• Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. (2006, unknown): “2003) that also binds to and represses the E-cadherin promoter (Jamora et al. 2003).”
• Therapeutic implications of cancer stem cells. (2004, background): “Additional studies implicate the Wnt/b-catenin pathway in the maintenance of stem-cell self-renewal in other tissues as well [11,12].”
• Socializing with the neighbors: stem cells and their niche. (2004, background): “The number of potential stem cell modifiers expressed by even this fraction of the niche cellulara negatively regulated target gene (Jamora et al., 2003).”
• The many faces and functions of β‐catenin (2012, unknown): “Binding of b -catenin to some target promoters can directly repress transcription, as reported for the genes E-cadherin in keratinocytes or p16INK4a in melanomas; in both studies, the binding of b -catenin to TCF lead to repression (Jamora et al , 2003; Delmas et al , 2007).”
• Normal stem cells and cancer stem cells: the niche matters. (2006, background): “which overrides BMP inhibition signaling, is required to activate stem cells, at least in skin and intestine (25, 51).”