Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila
By Andrew P Bailey, G. Koster, C. Guillermier, E. Hirst, James I. MacRae, C. Lechene, Anthony D. Postle, A. Gould. Cell, 2015
602 citations recorded by the source corpus.
Summary Stem cells reside in specialized microenvironments known as niches. During Drosophila development, glial cells provide a niche that sustains the proliferation of neural stem cells (neuroblasts) during starvation. We now find that the glial cell niche also preserves neuroblast proliferation under conditions of hypoxia and oxidative stress. Lipid droplets that form in niche glia during oxidative stress limit the levels of reactive oxygen species (ROS) and inhibit the oxidation of polyunsaturated fatty acids (PUFAs). These droplets protect glia and also neuroblasts from peroxidation chain reactions that can damage many types of macromolecules. The underlying antioxidant mechanism involves diverting PUFAs, including diet-derived linoleic acid, away from membranes to the core of lipid droplets, where they are less vulnerable to peroxidation. This study reveals an antioxidant role for lipid droplets that could be relevant in many different biological contexts.
Subfields: Biochemistry, Cellular and Molecular Neuroscience, Physiology
View Paper: https://www.semanticscholar.org/paper/734523ed6040218efb1f860a86d6aecd1b16fe44
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biochemistry
In Cellular and Molecular Neuroscience
In Physiology
Citations in the corpus
- The Science and Translation of Lactate Shuttle Theory. (2018, background): “Hence, it is not surprising that Bellen and colleagues (Liu et al., 2017) have described a neuron-glia lactate shuttle linked to lipid transfer that may be disrupted in Alzheimer’s disease (Bailey et al., 2015).”
- Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State (2019, positive): “Oxidizable PUFA-PLs are found in membranes throughout the cell, and mitochondria, lysosomes, and endoplasmic reticulum are all sites of lipid ROS accumulation during ferroptosis (Gaschler et al., 2018; Kagan et al., 2017; Krainz et al., 2016; Torii et al., 2016).”