In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus.

By Hoonkyo Suh, A. Consiglio, J. Ray, Toru Sawai, K. D’Amour, Fred H. Gage. 2007

847 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Neurology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “In another model, sex-determining region Y-box 2 (Sox2)-expressing nonradial cells with basal processes are active neural stem cells that give rise to new neurons and glia in the adult SGZ (Figure 1C) (Suh et al., 2007).”
Sox2+ adult stem/progenitor cells are important for tissue regeneration and survival of mice (2011, neutral): “Furthermore, except for neural stem cells (Suh et al., 2007), genetic fatemapping data to assess the lineage relationship between fetal and adult Sox2+ cells, aswell as that of Sox2+ adult cells and their putative progeny, are missing.”
Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus (2011, background): “However, our results do not exclude possibilities that DG contains small populations of Nestin-FP-expressing stem cells with repeated self renewal, stem cells with unusually long G2/M phases, or stem cells which are not detected using Nestin-driven reporter systems (Li and Clevers, 2010; Suh et al.,”
GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knock-in Mice (2009, background): “To test whether EGFP expression was localized to NSCs, we immunostained brain sections with antibodies against nestin, a cytoskeletal protein expressed predominantly in the processes of NSCs, and Sox2, another NSC marker in the brain (Suh et al., 2007).”
Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years (2010, background): “E, Transcription factor Sox2, characteristic for precursor cells, remains expressed in DCX+ cells lacking the transitional maturation marker calretinin.”
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics (2011, positive): “Consistent with previous observations (Lugert et al., 2010; Seri et al., 2001; Suh et al., 2007), nestin+GFAP+ RGLs were largely quiescent based upon MCM2 expression and MADM analysis.”
Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis (2010, background): “Prox1 Is Required for the Maintenance of Intermediate Progenitors in the SGZ During Adult Neurogenesis In the SGZ, Prox1 expression is initially detected in Tbr2 (Figure 6E) [35] and Dcx (Figure 6F) Type-IIb intermediate progenitors [36] and is absent from adult NSCs (Figure 6A,B,C) [37,38] and Ascl”
Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. (2010, background): “All our studies supported this notion, demonstrating that (1) BMP canonical signaling is active in the majority of the SOX2 cell population in the hippocampus, which is predominantly out of the cell cycle (Suh et al., 2007), including the BMPRI-A radial stem cell pool; (2) BMP canonical signaling is”
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis (2011, methodology): “By using single BrdU injections and previously characterized marker proteins for NSCs and their progeny, we found Prox1 to be expressed as early as in the nonradial stage of SOX2-expressing cells in theDG (24) (Fig.”
Mechanisms and functional implications of adult neurogenesis. (2008, positive): “The transcription factor Sox2 is important for maintaining the ‘‘stemness’’ not only of certain types of adult stem cells including NSCs but also of embryonic stem (ES) cells; as part of a four-factor cocktail, Sox2 contributes to inducing adult somatic cells to take on an ES cell-like fate (see Rev”
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. (2009, background): “Newborn granule cells pass through several developmental steps, from a dividing progenitor to a mature granule cell that becomes indistinguishable from granule cells born during embryonic development (Kempermann et al. 2004; Laplagne et al. 2006; Suh et al. 2007).”
SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma (2009, background): “…(see Figure S1A available online), and expressed high levels of stem cell-associated proteins such as Nestin (Lendahl et al., 1990), Sox2 (Suh et al., 2007; Yuan et al., 1995), Bmi1 (Lessard andSauvageau, 2003), and Ezh2 (Shenet al., 2008; Sher et al., 2008; Valk-Lingbeek et al., 2004)…”
Substrate modulus directs neural stem cell behavior. (2008, background): “Adult NSCs (24,34,39) have different functional roles in vivo than do previously studied cells, including primary late embryonic neural cultures (21,41,48) or early postnatal differentiated neurons (20).”
Sox1 marks an activated neural stem/progenitor cell in the hippocampus (2012, background): “By contrast, SOX2 expression has been well characterized in adult neurogenic zones (Ellis et al., 2004; Ferri et al., 2004; Komitova and Eriksson, 2004; Brazel et al., 2005; Episkopou, 2005; Sottile et al., 2006; Suh et al., 2007).”