Regulation of Mitochondrial Biogenesis in Skeletal Muscle by CaMK

By Hai Wu, S. Kanatous, F. Thurmond, T. Gallardo, E. Isotani, R. Bassel-Duby, R. S. Williams. Science, 2002

723 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/09f42736d8703901f207c7d71c898a881c9ef202

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Citations in the corpus

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. (2006, background): “Comparable changes in muscle fiber types have been recapitulated in genetically engineered mouse models that trigger calcium regulatory pathways (Wu et al., 2002), mimic PPARb/d activation (Wang et al.”
Metabolic control through the PGC-1 family of transcription coactivators. (2005, background): “…Huss et al., 2002; Huss et al., 2004; Kamei et al., 2003; ERRα,β,γ + + mitochondrial genes Mootha et al., 2004; Schreiber et al., 2004 TRβ + + cpt-1 induction Wu et al., 2002; Zhang et al., 2004b; Shin et al., 2003 LXRα,β + + lipoprotein secretion Lin et al., 2005; Oberkofler et al., 2003 FXR + ND…”
Transcriptional paradigms in mammalian mitochondrial biogenesis and function. (2008, background): “Calcium signaling has also been associated with a PGC-1-dependent pathway of mitochondrial biogenesis in skeletal muscle (155, 235).”
Regulation of Muscle Fiber Type and Running Endurance by PPARδ (2004, background): “…described here are remarkably similar to those of transgenic mice expressing either calcineurin, calmodulin-dependent kinase, or PGC-1 a (Naya et al. 2000; Lin et al. 2002; Wu et al. 2002), indicating that PPAR d could be one of the hypothetical downstream transcription factors of these pathways.”
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. (2004, background): “First, overexpression of CaMK in the skeletal muscle of transgenic mice triggers a robust mitochondrial biogenesis associated with an induction of PGC-1 expression (Wu et al. 2002).”
Regulation of mitochondrial biogenesis (2010, background): “In addition, mRNA expression of cytochrome b and carnitine palmitoyltransferase-1 was increased in the transgenic mice [23].”
The Mitochondrial Basis of Aging (2016, background): “…by a number of physiological adaptations; however, one of the most beneficial effects appears to be stimulation of mitochondrial biogenesis in a wide variety of tissues, including the brain (Arany et al., 2005; Egan and Zierath, 2013; Rowe et al., 2014; Steiner et al., 2011; Wu et al., 2002).”
Exercise metabolism and the molecular regulation of skeletal muscle adaptation. (2013, background): “CaMKs and calcium signaling influence glucose transport (Wright et al., 2004), lipid uptake and oxidation (Raney and Turcotte, 2008), and skeletal muscle plasticity (Wu et al., 2002).”
Disordered lipid metabolism and the pathogenesis of insulin resistance. (2007, neutral): “Together, these data suggest that alterations in nuclear-encoded genes that regulate mitochondrial biogenesis such as PPAR- coactivator 1 (PGC-1 ), AMP kinase (7, 132), and calmodulin IV kinase (125) may form the genetic basis for inheritance of at least some forms of T2DM.”
Cell and Molecular Biology (2009, background): “, 1999), specifically CaMKII and CaMKIV (Rose et al., 2007; Wu et al., 2002) and calcineurin, a calcium–calmodulin (CaM)-dependent protein phosphatase (Bigard et al.”
Transcriptional control of mitochondrial biogenesis and function. (2009, background): “Second, transgenic mice expressing constitutively active calcineurin or CAMKIV in muscle show increased mtDNA content, mitochondrial volume, and PGC-1α levels (143, 144).”
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. (2005, methodology): “subsarcolemmal mitochondria, using a previously published method (28).”