The Mitochondrial Basis of Aging

By Nuo Sun, R. Youle, Toren Finkel. Molecules and Cells, 2016

1,280 citations recorded by the source corpus.

A decline in mitochondrial quality and activity has been associated with normal aging and correlated with the development of a wide range of age-related diseases. Here, we review the evidence that a decline in mitochondria function contributes to aging. In particular, we discuss how mitochondria contribute to specific aspects of the aging process including cellular senescence, chronic inflammation and the age-dependent decline in stem cell activity. Signaling pathways regulating the mitochondrial unfolded protein response and mitophagy are also reviewed with particular emphasis placed on how these pathways might in turn regulate longevity. Taken together, these observations suggest that mitochondria influence or regulate a number of key aspects of aging, and suggest that strategies directed at improving mitochondrial quality and function might have far-reaching beneficial effects.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/b8ae61345f5be0644ee51f942297f2a2884599c2

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Citations in the corpus

Mitochondrial dysfunction in cell senescence and aging (2022, background): “During mitochondrial dysfunction, low MMP is typically associated with increased production of reactive oxygen species (ROS) (32, 33); however, empirical determination of ROS is required for each case to confirm this.”
Senescence and aging: Causes, consequences, and therapeutic avenues (2018, background): “For example, senescent cells display decreased mitophagy, resulting in an “old,” defective mitochondrial network that may contribute to metabolic dysfunction in age (Sun et al., 2016).”
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances (2025, neutral): “222 229 Mitochondrial dynamics .”
Mechanisms and functions of cellular senescence. (2018, neutral): “Also, senescent cells display decreased levels of mitophagy (mitochondrial autophagy), which results in a defective mitochondrial network that may contribute to metabolic dysfunction in aging (115).”
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, methodology): “The development of strategies to treat this impairment of mitophagy would benefit from the screening and identification of new mitophagy regulators.(521,522) Recently, a research team used a combination of unsupervised machine learning (including vector representation of molecular structure, pharmac”
Benefits of Metformin in Attenuating the Hallmarks of Aging (2020, background): “Mitochondrial dysfunction—There is longstanding evidence that the decline in mitochondrial function with aging, may contribute to age-associated dysregulation in energy homeostasis and increased predisposition to age-related diseases (Sun et al. 2016).”
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “There is also an association between senescent cells and the dysregulated mitochondrial network and associated metabolic dysfunction that is seen with increasing age (97).”