Cell and Molecular Biology
By P. Russell. 2009
232 citations recorded by the source corpus.
Focal adhesions have been intensely studied ever since their discovery in 1971. The last threedecadeshave seenmajor advances inunderstanding thestructureof focal adhesions and the functions they serve in cellular adhesion, migration, and otherbiological processes. In this chapter,webeginwith ahistorical perspective of focal adhesions, provide an overview of focal adhesion biology, and highlight recent major advances in the field. Specifically, we review the different types of matrix adhesions and the role different Rho GTPases play in their formation. We discuss the relative contributions of integrin and syndecan adhesion receptors to the formation of focal adhesions. We also focus on new insights gained from studying focal adhesions on biomaterial surfaces and from the growing field of mechanotransduction. Throughout this chapter, we have highlighted areas of focal adhesion biology where major questions still remain to be answered.
Subfields: Cancer Research
View Paper: https://www.semanticscholar.org/paper/9d8666641924aad8977f12efc4fbf738154f1254
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In Cancer Research
Citations in the corpus
- Review on Cell Mechanics: Experimental and Modeling Approaches (2013, background): “The cellular membrane is composed of a thin lipid bilayer, which is approximately 5–10 nm in thickness [17] and has a bending stiffness of 10 À19 –10 À20 N Á m [18].”
- Neuronal calcium signaling: function and dysfunction (2014, background): “SNARe superfamily (see [122] for a comprehensive coverage of the topic).”
- Translation-invariant monotone systems, and a global convergence result for enzymatic futile cycles ☆ (2008, background): “An excellent discussion can be found in [22], which also points out that futile cycles play a central role in signaling processes ranging from GTPase cycles [7] and mitogen-activated protein cascades [9,18] to glucose mobilization [17], actin treadmilling [4], bacterial two-component systems and pho”