Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
By Kristin J. Hope, Liqing Jin, J. Dick. Nature Immunology, 2004
1,019 citations recorded by the source corpus.
Subfields: Hematology, Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/09e4c8bd95e5b395a16f11afe5a38f6af8d95bd4
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Citations in the corpus
- The biology of cancer stem cells. (2007, background): “These events are not surprising, given the heterogeneity of the LSC population (Hope et al. 2004) and the inherent genomic instability of an uncontrolled population of transforming cells (Bayani et al. 2007).”
- Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients (2008, background): “These so-called CSCs have been described to be organized as a hierarchy of stem cells and various types of progenitor cells that are locally restricted to a stem cell niche (2).”
- Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized (2010, background): “To test whether the proliferative capacity of some tumorigenic melanoma cells may be limited, as observed in some human leukemia-initiating cells (Hope et al., 2004), we formed melanomas in NSG mice from single cells derived from six patients (32 tumors arose from the injection of 58 single cells).”
- Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region (2007, background): “dtd" [ ]> Acute myelogenous leukemia (AML) is the most common adult leukemia, characterized by the clonal expansion of immature myeloblasts initiating from rare leukemic stem (LS) cell”
- Nanomedicine therapeutic approaches to overcome cancer drug resistance (2013, background): “Cancer stem cells have also been isolated from medulloblastoma, glioblastoma [41], ependymoma [42], colon cancer [43,44], chronic and acute myeloid leukemia [45], pancreatic cancer [46], and head and neck squamous cell carcinomas [47].”
- Cancer stem cells: lessons from leukemia. (2005, background): “Recently, the use of lentiviral gene marking to track the behaviour of individual SL-ICs following serial transplantation has revealed heterogeneity in their ability to repopulate secondary and tertiary recipients, pointing to the existence of distinct classes of LSC with differing self-renewal capa”
- Cancer stem cells: an old idea--a paradigm shift. (2006, background): “This supports the hypothesis that leukemic stem cells originate from the transformation of normal hematopoietic stem cells (29).”
- Tissue repair and stem cell renewal in carcinogenesis (2004, background): “, and was firmly established experimentally in acute myelogenous leukaemia (AML”
- Cells of origin in cancer (2011, background): “Human acute myeloid leukaemia (AML) may originate within the primitive haematopoietic cell compartment, on the basis of the similar cell-surface phenotypes of the leukaemia-initiating cell and the HSC, as well as lentivirus-mediated clonal-tracking studie”
- Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. (2005, background): “Such approaches have been extensively investigated in leukemia (2, 3) and indicate that along with the establishment of a hierarchy, the transformed leukemic blast stem cells may be differentiation arrested (4).”
- Cancer stem cells in solid tumours: accumulating evidence and unresolved questions (2008, background): “Ultimately, it is essential to demonstrate that solid tumours can be formed from a single transplanted CSC, analogous to the lentiviral tagging of acute myeloid leukaemia cell”
- Brain tumour stem cells (2006, neutral): “The latter hypothesis fits with the cancer-stem-cell theory and is now supported by a plethora of recent observation”