p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases.

By Kurt Zatloukal, C. Stumptner, A. Fuchsbichler, H. Heid, M. Schnoelzer, L. Kenner, R. Kleinert, Marco Prinz, A. Aguzzi, H. Denk. American Journal of Pathology, 2002

642 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/09b4cc8dd325fc22816ad56dff3049fc9c9ab387

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Citations in the corpus

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells (2011, background): “Induction of Nrf2 target genes has been recognized in many human cancers (Hayes and McMahon, 2009) that also show p62 accumulation (Zatloukal et al., 2002).”
Astrocytes: a central element in neurological diseases (2016, neutral): “and synemin [146, 176, 225, 263], although the exact pro-”
Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. (2014, background): “…in aggregates positive for Ub, and p62 is a marker for inclusion bodies found in cells of patients with various forms of proteinopathies, such as Mallory bodies in alcoholic liver disease and protein aggregates in neurodegenerative diseases (Kuusisto et al., 2001; Zatloukal et al., 2002).”
The LIR motif – crucial for selective autophagy (2013, background): “…NF-kB (Moscat et al., 2007), but to also accumulate in ubiquitin-containing protein inclusions in many proteinaggregation diseases including Alzheimer disease, Pick disease, dementia with Lewy bodies, Parkinson disease and multiple system atrophy (Kuusisto et al., 2001; Zatloukal et al., 2002).”
Autophagy: Renovation of Cells and Tissues (2011, background): “Similar inclusion bodies with p62 and ubiquitin have been identified in various neurodegenerative diseases, including Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis; liver disorders, including alcoholic hepatitis and steatohepatitis; and cancers, including malignant glioma a”
Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. (2011, background): “Indeed, p62 is detected as a common component of neuronal protein inclusions that are a major characteristic of neurodegenerative disease in humans and mouse models (Nagaoka et al., 2004; Zatloukal et al., 2002).”
A role for ubiquitin in selective autophagy. (2009, background): “Ub-positive inclusion bodies have been found positive for p62 (Nagaoka et al., 2004; Zatloukal et al., 2002).”