A role for ubiquitin in selective autophagy.

By V. Kirkin, David G. McEwan, I. Novak, Ivan Dikic. Molecules and Cells, 2009

1,263 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d02c40821d9eaf459f088569225bd6ca4a56b866

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Citations in the corpus

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62 (2010, background): “It was originally characterized as an interacting partner of atypical protein kinase C (aPKC), which is mediated through the Phox and Bem1p (PB1) domain, a domain conserved on the N terminus of p62 that can cause p62 to either homodimerize or heterodimerize with the PB1 domain of other proteins (6).”
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences (2012, neutral): “Selective autophagy requires speciﬁc labelling of the substrates destined for degradation, such as ubiquitination, and subsequent binding of adaptor proteins to recruit the autophagic machinery to the tagged cargo (reviewed in Kirkin et al , 2009).”
Mitophagy: mechanisms, pathophysiological roles, and analysis (2012, background): “Emerging evidence has suggested that ubiquitination plays a critical role in the selective removal of protein aggregates, peroxisomes, ribosomes, and invading bacteria by autophagy (Kirkin et al. , 2009 ).”
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells (2011, background): “Although autophagy has generally been considered nonselective, recent studies have shed light on another indispensable role for basal autophagy in cellular homeostasis, which is mediated by selective degradation of a specific substrate(s) (Kirkin et al., 2009; Kraft et al., 2010; Johansen and Lamark”
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy (2014, background): “While ATG8 proteins are known to recruit a small number of cargo receptors to insipient autophagosomes, the full repertoire of selective autophagic cargo and their cognate receptor proteins remain poorly defined 3 .”
Cellular strategies for controlling protein aggregation (2010, background): “or acidic hydrolases after their transport into the lysosomal compartmen”
Molecular definitions of autophagy and related processes (2017, positive): “…et al , 2005; Komatsu et al , 2007; Pankiv et al , 2007; Kirkin et al , 2009b), NBR1 (an orthologue of which participates in plant aggrephagy) (Kirkin et al , 2009a,b), OPTN (Korac et al , 2013), and toll-interacting protein (TOLLIP) (Lu et al , 2014b), as well as the p62-binding proteins WD…”
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I (2020, positive): “Recent studies have revealed that autophagy can selectively degrade target molecules using autophagy cargo receptor proteins that bind to and recruit substrates to autophagosomal membranes 15 .”
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both (2010, positive): “While polyubiquitinated proteins with linkages other than K63 (the most common of which is K48) are usually targeted for degradation by the proteasome, K63-linked chains are thought to serve a signaling function and have been implicated in DNA repair, activation of NF-KappaB signaling, sorting of en”
Autophagy gone awry in neurodegenerative diseases (2010, neutral): “Although macroautophagy was previously considered an 'in-bulk' process, overwhelming evidence now supports selectivity in the sequestration of autophagic carg”
Nix is a selective autophagy receptor for mitochondrial clearance (2010, background): “gif" NDATA ITEM>]> Introduction Mounting evidence suggests that selective degradation of bulky cytosolic substrates, such as protein aggregates, damaged organelles and intracellular microbes, is mediated by macroautophagy (autophagy hereafter”
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. (2013, background): “…of evidence has demonstrated the importance of selective autophagy, which degrades aggregated proteins (aggrephagy), unnecessary or damaged mitochondria (mitophagy), and invading bacteria (xenophagy) via ubiquitin signaling (Deretic and Levine, 2009; Kirkin et al., 2009; Youle and Narendra, 2011).”
Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. (2014, background): “…identification and characterization of selective autophagy receptors, such as mammalian p62/SQSTM1 (sequestosome-1, also known as p62) and yeast Atg19, which link the cargo to the autophagic machinery and elicit directed autophagosome formation (Johansen and Lamark, 2011; Kirkin et al., 2009b).”