Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.

By Gen Matsumoto, K. Wada, Misako Okuno, M. Kurosawa, N. Nukina. Molecules and Cells, 2011

689 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a04b9c615ce535c26431e276829449c26f2d1450

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Citations in the corpus

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. (2013, background): “Coupling of the Keap1-Nrf2 System to Autophagy the ubiquitinated cargos (Matsumoto et al., 2011; Pilli et al., 2012).”
p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation (2016, neutral): “This increased affinity can stabilize ubiquitinated proteins in the sequestosome, which, in turn, prevents p62 dephosphorylation and leads to efficient degradation of the protein aggregates [74].”
The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of TBK1 activation and recruitment of OPTN and NDP52 to promote mitophagy (2015, background): “…UBA domains in SQSTM1, UBAN and ZNF domains in OPTN and UBZ domains in NDP52, which preferentially bind K63 chains as well as linear chains in the case of OPTN (Gleason et al., 2011; Laplantine et al., 2009; Matsumoto et al., 2011; Ordureau et al., 2015a; Sims et al., 2012; van Wijk et al., 2012).”
Mechanisms of Selective Autophagy (2016, neutral): “The affinity of p62 for ubiquitin can be increased by phosphorylation of serine 403 within the UBA domain [52].”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “anti-phospho-SQSTM1 antibodies can be used to detect the modified form of the protein.(324)”
TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation (2012, neutral): “Anti-phospho-S403 p62 antibody (Matsumoto et al., 2011) was from N. Nukina.”
Mitophagy: mechanisms, pathophysiological roles, and analysis (2012, neutral): “Keywords: autophagy; mitophagy; Nix; Parkin.”
Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. (2014, background): “The UBA domain of p62 preferentially interacts with Lys63-polyUb chains, and the affinity of the interaction is subject to regulation by UBA phosphorylation (Matsumoto et al., 2011; Pilli et al., 2012).”
Ubiquitination and selective autophagy (2012, methodology): “phosphorylation of serine 403 in the UBA domain of p62 by casein kinase 2 was shown to enhance the binding to ubiquitin chains.(65) Thus, recruitment of several kinases to the vicinity of bacteria targeted by autophagy might ensure”