The Salvador–Warts–Hippo pathway — an emerging tumour-suppressor network

By K. Harvey, N. Tapon. Nature Reviews. Cancer, 2007

658 citations recorded by the source corpus.

Subfields: Cell Biology

View Paper: https://www.semanticscholar.org/paper/99c3b2983c5c65c184cd26ae75c9d8c495b9188b

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In Cell Biology

1. K. Guan
2. Bin Zhao
3. G. Halder
4. Duojia Pan
5. S. Piccolo
6. Yonggang Zheng
7. Fa-Xing Yu
8. Li Li

Citations in the corpus

• The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. (2008, background): “Studies in recent years, primarily conducted in the fruit fly Drosophila, have implicated the Hippo (Hpo) signaling pathway as a central mechanism that regulates organ size by controlling both cell proliferation and cell death (Edgar, 2006; Pan, 2007; Harvey and Tapon, 2007).”
• The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development (2008, background): “The mammalian Hippo pathway also contributes to organ size control [51,52] and dysregulation of numerous Hippo pathway components, including Mer, Sav, Lats and YAP, has been observed in human tumors [48,53].”
• Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (2007, background): “In addition, mutations of Lats1/2, Sav, and Mob have been implicated in tumorigenesis (St John et al. 1999; Tapon et al. 2002; Lai et al. 2005; Takahashi et al. 2005; Harvey and Tapon 2007).”
• MicroRNA control of signal transduction (2010, background): “The core protein engines of developmental signalling networks are highly conserved devices, which can be traced back to the common ancestor of all Bilateri”
• TEAD mediates YAP-dependent gene induction and growth control. (2008, background): “Recent genetic studies in Drosophila have identified a novel tumor suppressor pathway, the Hippo pathway (Harvey et al. 2003; Wu et al. 2003; Lai et al. 2005; Edgar 2006; Hariharan and Bilder 2006; Harvey and Tapon 2007).”
• Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration (2011, background): “melanogaster with inactive forms of both RB and Hippo (a member of the STE20 family of protein kinases”
• Involvement of members of the cadherin superfamily in cancer. (2009, background): “In the fly, Fat modulates cell contact inhibition and organ size by functioning upstream of the (Hippo/Salvador)-(Warts/Mats)-YorkieScalloped signaling pathway (reviewed in Harvey and Tapon 2007; Zeng and Hong 2008; Zhao et al. 2008).”