Cancer stem cells: mirage or reality?

By Piyush B. Gupta, Christine L. Chaffer, R. Weinberg. Nature Medicine, 2009

1,001 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/074b6c745ec4c45ddb00e8cc9e50ba8510355b13

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Citations in the corpus

Hallmarks of cancer: the next generation. (2011, neutral): “Nevertheless, the importance of CSCs as a distinct phenotypic subclass of neoplastic cells remains a matter of debate, as does their oft-cited rarity within tumors (Boiko et al., 2010; Gupta et al., 2009; Quintana et al., 2008).”
Oxygen in stem cell biology: a critical component of the stem cell niche. (2010, background): “Onemajor breakthrough in cancer biology has been the isolation and characterization of cancer stem cells (CSCs) (Gupta et al., 2009; Ward and Dirks, 2007).”
The ins and outs of the epithelial to mesenchymal transition in health and disease. (2011, background): “A couple important concepts regarding cancer and epithelial plasticity have emerged in the past few years: (a) the existence of stem cell properties in tumors and (b) the contribution of so-called cancer stem cells (CSCs) to the initiation of the tumor and the formation of metastases.”
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis (2022, background): “Since then, this feature has been found in many CSC subpopulations and other studies have reported that high intracellular ALDH1 activity is a marker of stemness [246, 247].”
Evolution of the cancer stem cell model. (2014, background): “Thus, it will be important to determine the probability of being in one state versus another and the factors that inﬂuence such interconversions (Gupta et al., 2009).”
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. (2013, background): “Accordingly, it was recently suggested that dedifferentiation of nonstem cells triggered by signals from the inflammatory microenvironment may also lead to the generation of cancer stem cells (Gupta et al., 2009; Hanahan and Weinberg, 2011).”
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. (2011, background): “…the potential of self-renewal is an exclusive property of CSCs, or whether plasticity exists in these hierarchical lineages, such that any cell, even a non-CSC, could acquire self-renewal potential under appropriate intrinsic or extrinsic cues (Chaffer and Weinberg, 2011; Gupta et al., 2009).”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “CSCs were first identified in leukaemias (Lapidot et al., 1994) and later shown to be crucial for certain solid tumours (Gupta et al., 2009), although their relevance for other tumours, such as melanoma, remains unclear (Quintana et al., 2008).”
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer (2010, background): “However, whether CSCs are truly the only cells with de facto tumorigenic potential remains controversial (Quintana et al., 2008; Gupta et al., 2009a).”
Anoikis: an emerging hallmark in health and diseases (2012, background): “So the acquisition of stem cell features, linked to both EMT [107,108] and ROS production [109], may contribute to the survival and subsequent proliferation of cancer cells.”
The Roles of Autophagy in Cancer (2018, background): “Cancer stem-cells (CSC) are a small subpopulation of cancer cells that have the abilities of self-renewal and differentiation and contribute to tumor initiation, chemoresistance, and metastasis [135,136].”
The therapeutic promise of the cancer stem cell concept. (2010, background): “Microenvironmental factors can also markedly influence cancer cell tumorigenicity in xenotransplantation models (15), as shown for human melanoma, in which exogenously added ECM factors normally produced by tumor cells markedly enhanced tumorigenic”
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer (2009, background): “Yet a lot of interest has been paid recently to cancer stem cell research [247, 248], although the existence of such cells has been questioned [249].”
The Role of Snail in EMT and Tumorigenesis (2013, background): “Increasing evidence suggests that tumors develop and progress from a small subset of cells with the ability to self-renew and produce nonstem differentiated cells [88].”