The Role of Snail in EMT and Tumorigenesis

By Yifan Wang, Jian-Ting Shi, Kequn Chai, Xuhua Ying, Binhua P. Zhou. Current Cancer Drug Targets, 2013

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Epithelial-mesenchymal transition (EMT) is a highly conserved process in which polarized, immotile epithelial cells lose adherent and tight junctions, and become migratory mesenchymal cells. As a key transcriptional repressor of E-cadherin expression in EMT, Snail plays an important role in embryonic development and cancer progression. Emerging evidences indicate that Snail confers tumor cells with cancer stem cell-like traits, and promotes drug resistance, tumor recurrence and metastasis. In this review, we summarize recent developments underlying the regulation and functions of Snail in tumor progression, and discuss new approaches against EMT in preventing metastatic cancers.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/873ba3a6f336dbbad5c771ff39a09287904bfdea