The therapeutic promise of the cancer stem cell concept.

By N. Frank, T. Schatton, M. Frank. Journal of Clinical Investigation, 2010

640 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/be7faac6d57d088b6ae39bcc56c204dd61d6e33b

How researchers see this paper

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In Molecular Biology

1. M. Greaves

In Oncology

1. Carlo C. Maley
2. M. Greaves

Citations in the corpus

• Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways (2011, background): “Self-renewing CSCs, comprising a small minority of tumor cells, initiated tumor growth and formed new progenitor and bulk tumor cells in severe combined immunodeficient (SCID) mice”
• Drug resistance and combating drug resistance in cancer (2019, background): “CSCs are a subpopulation in tumors with the capacity of selfrenewal and differentiation, participating in tumor initiation and progression[28].”
• CLONAL EVOLUTION IN CANCER (2012, background): “The adaptability of cancer stem cells provided by genetic diversity is added to by what seems to be their intrinsically lowered susceptibility to drugs and irradiatio”