The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

By Mitsutoshi Yoneyama, M. Kikuchi, T. Natsukawa, N. Shinobu, T. Imaizumi, M. Miyagishi, K. Taira, Shizuo Akira, T. Fujita. 2004

4,202 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

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Citations in the corpus

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “poly(rC)-induced signalling in a functional screen (Yoneyama et al., 2004) and binds to poly(rI).”
Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I (2016, neutral): “R Acid Inducible Gene-I (RIG-I) is a cytosolic innate immune receptor with the remarkable ability of distinguishing cellular self RNAs from pathogenic nonself RNAs (1, 2).”
A structure-based model of RIG-I activation. (2012, background): “RIG-I and MDA-5 complement each other by responding to distinct types of RNAs from different viruses (Yoneyama et al. 2005; Kato et al. 2006; Loo and Gale 2011).”
Pathogen recognition and innate immunity. (2006, positive): “Retinoic-acid-inducible protein I (RIG-I) is an IFNinducible protein containing CARDs and a DExD/H box helicase domain and has been identified as a cytoplasmic dsRNA detector (Figure 3) (Yoneyama et al., 2004).”
Recognition of microorganisms and activation of the immune response (2007, background): “Viral RNA in the cytosol is detected by the RNA-helicase-family proteins RIG-I and MDA5 (ref”
Toll-like receptors in innate immunity. (2004, positive): “Studies with ectopic expression and RNA interference (RNAi)-mediated knockdown of RIG-I clearly demonstrated that RIG-I is critical in dsRNA-and viral infection-induced type I IFN expression (54).”
MDA5/RIG-I and virus recognition. (2008, background): “RIG-I (also known as DDX58) was identified as a candidate for a cytoplasmic viral RNA detector [5].”
NLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing responses to influenza A virus via the regulation of caspase-1 (2009, positive): “The ssRNA influenza virus genome has been shown to activate the TLR7 and RIG-I pathways in APCs such as macrophages and dendritic cells (Diebold et al., 2004; Pichlmair et al., 2006).”
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3 (2005, positive): “The receptor that detects intracellular dsRNA generated by the virus is a newly identified protein RIG-I, which contains two N-terminal CARD-like domains, and a C-terminal RNA helicase domain that binds to dsRNA (Sumpter et al., 2005; Yoneyama et al., 2004 ).”
Defining the functional determinants for RNA surveillance by RIG-I (2013, neutral): “The pathogen-associated molecular pattern (PAMP) of RIG-I is generally defined as duplex RNA containing a 5 0 triphosphate moiety [6–8], although only duplex RNA is absolutely required for RIG-I recognition [9].”
Establishing the role of ATP for the function of the RIG-I innate immune sensor (2015, background): “While robust signaling is often associated with ATP hydrolysis activity (Yoneyama et al., 2004; Bamming and Horvath, 2009; Luo et al., 2011; Kohlway et al., 2013; Patel et al., 2013; Peisley et al., 2013; Rawling et al., 2015), the ability of an RNA ligand to stimulate RIG-I ATPase activity does…”
Innate Immunity to Virus Infection (2009, background): “The helicase domain and RD are important for the recognition of these RNAs, while the CARDs are essential for triggering intracellular signaling cascades (6, 12).”