Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

By Rashu B. Seth, Lijun Sun, Chee-Kwee Ea, Zhijian J. Chen. Cell, 2005

3,083 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/fc837ad439a6594107d3adfa801e10a1d971b8c1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shizuo Akira
2. Zhijian J. Chen
3. O. Takeuchi
4. S. Ghosh
5. Taro Kawai
6. Satoshi Uematsu
7. M. Hayden
8. A. West

In Oncology

1. Shizuo Akira
2. Zhijian J. Chen
3. O. Takeuchi
4. Satoshi Uematsu
5. S. Ghosh
6. M. Hayden
7. Lijun Sun
8. M. Gale

Citations in the corpus

• The interferon response circuit: Induction and suppression by pathogenic viruses (2005, background): “The novel protein is required to mediate RIG-I and MDA5 signals to downstream factors and is therefore called either IPS-1 for ‘‘interferon-hpromoter stimulator 1’’ (Kawai et al., 2005) or MAVS for ‘‘mitochondrial antiviral signaling’’ molecule (Seth et al., 2005).”
• Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases (2008, background): “RLRs interact with a central adaptor IFNB -promoter stimulator 1 (IPS1; also known as MAVS, VISA or CARDIF”
• NF-κB and the immune response (2006, background): “Recently, a CARD-containing protein, variably named CARDIF, IPS1, MAVS and VISA, has been implicated downstream of RIG-I; however, the link between this protein and IKKb is unclear (Kawai et al., 2005; Meylan et al., 2005; Seth et al., 2005; Xu et al., 2005).”
• Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High Affinity Ligand for STING (2013, neutral): “MAVS, an essential adaptor protein of the RIG-I pathway (Seth et al., 2005), was able to induce IFNb in all of these cell lines.”
• IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors (2006, neutral): “and MAVS (mitochondrial antiviral signalling protein”
• Peroxisomes are signaling platforms for antiviral innate immunity (2010, neutral): “MAVS-Cyto cells were unable to induce viperin expression, confirming thatmembrane localization isnecessary for MAVS function (Seth et al., 2005).”