Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I
By S. Devarkar, Chen Wang, Matthew T. Miller, Anand Ramanathan, F. Jiang, A. Khan, Smita S. Patel, J. Marcotrigiano. 2016
313 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- Anna Marie Pyle
- Wenshuai Wang
- Megan E. Fitzgerald
- David C. Rawling
- Andrew S. Kohlway
- O. Potapova
- Smita S. Patel
- J. Marcotrigiano
In Molecular Biology
- Anna Marie Pyle
- Wenshuai Wang
- Megan E. Fitzgerald
- David C. Rawling
- Andrew S. Kohlway
- J. Marcotrigiano
- Chen Wang
- S. Devarkar
Citations in the corpus
- The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands (2022, methodology): “…conditions, using RIG-I truncation constructs employed in different laboratories, which makes it difficult to compare features that enable RIG-I to differentiate host and viral RNAs (Devarkar et al., 2016; Jiang et al., 2011; Kohlway et al., 2013; Kowalinski et al., 2011; Luo et al., 2011, 2012).”
- RIG-I uses an ATPase-powered translocation-throttling mechanism for kinetic proofreading of RNAs and oligomerization (2018, background): “Although RIG-I has a lower affinity for nonPAMPs, differences in the binding affinities for PAMP and non-PAMP RNAs (~20–500 fold) are not sufficient to explain the high selectivity of RIG-I activation (Devarkar et al., 2016; Kohlway et al., 2013; Ramanathan et al., 2016).”
- Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding (2016, background): “In many of the structures, including the apoform (PDB ID: 4A2W) (10), the RNA bound form (PDB ID: 2YKG, 3ZD6, 4BPB, 5F9F, 5F9H) (9,41,46) and the RNA–ADP bound form (PDB ID: 4AY2) (20), Ser411 interacts directly with Met761 (762 in duck), which is a residue within helix 1 of the Pincer domain.”
- mRNA capping: biological functions and applications (2016, unknown): “The ability to generate cap 0 and cap 1 RNAs in vitro have also been invaluable in researching the role of the G cap and its 2 O methylation in innate immunity (2,68,76,81).”
- Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants (2018, background): “ribonucleic acids for instance are shielded from RLRs by introducing 2’O-methylations or by destabilizing double-stranded parts through A-to-I editing (Chung et al., 2018; Devarkar et al., 2016; Liddicoat et al., 2015; Schuberth-Wagner et al., 2015).”