Autophagy as a cell death and tumor suppressor mechanism

By Devrim Gozuacik, Adi Kimchi. Oncogene, 2004

1,487 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Parasitology

View Paper: https://www.semanticscholar.org/paper/0621e0eb0e695421e559210ad3fa5805e8197d15

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

In Epidemiology

In Parasitology

Citations in the corpus

Revisiting the hallmarks of cancer. (2017, neutral): “Autophagy (macroautophagy, the most widely described type) is a recycling process of intracellular components that physiologically serves a quality-control function, operating at a low basal rate, removing pathologic long-lived or misfolded proteins and damaged organelles [57], and may also be invol”
Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment (2010, background): “However, we detected significantly higher amounts of the autophagy-associated protein beclin-1 (ref”
Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study (2005, background): “The intriguing influences of macroautophagy on cellular aging mechanisms, cell survival, and protein handling that emerges from recent studies (26, 33, 76, 77) suggest that an understanding of its roles in neurons will be highly informative in defining pathogenic mechanisms in AD.”
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury (2005, background): “, has been implicated in caspase-independent cell deat”
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG (2006, background): “However, excessive autophagy results in autophagic cell death that is morphologically distinct from apoptosi”
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. (2007, background): “It has been suggested that the ability of radiation or chemotherapy to induce cell death in cancer cell lines that display resistance to apoptosis depends on type II programmed cell death executed by autophagy (40).”
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease (2005, neutral): “…L O F C E L L B IO L O G Y © The Rockefeller University Press $8.00 The Journal of Cell Biology, Vol. 171, No. 1, October 10, 2005 87–98 http://www.jcb.org/cgi/doi/10.1083/jcb.200505082 JCB: ARTICLE JCB 87 Macroautophagy—a novel -amyloid peptide-generating pathway activated in Alzheimer’s disease”
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis (2006, background): “A portion of the cytoplasm is sequestered in an autophagosome and its contents are degraded on fusion with lysosome”
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis (2007, background): “cerevisiae and can be categorized into four functional groups: (1) the Atg1 protein kinase complex regulating the induction of autophagy, (2) the class III PI3-kinase (PI3KC3) lipid kinase complex controlling vesicle nucleation, (3) the Atg12-Atg5 and Atg8phosphatidylethanolamine conjugation pathway”
The role of autophagy in cancer development and response to therapy (2005, background): “Increasing evidence indicates the importance of autophagy in cance”