Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

By Ralph A. Nixon, J. Wegiel, Asok Kumar, W. H. Yu, Corrinne M. Peterhoff, A. Cataldo, A. Cuervo. Journal of Neuropathology and Experimental Neurology, 2005

1,558 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/22f294434f6f4fbac47abf9aeccd194ff05ac366

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Citations in the corpus

Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future (2023, background): “Accumulation of immature autophagosome in dystrophic neurites has been observed in the brain of Alzheimer’s patients due to the defective axonal transportation of autophagosomes.(498) Thus, autophagy modulation becomes a promising stategy for Alzheimer’s treatment.”
Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “with Gerstmann-Sträussler-Scheinker (GSS) disease not unlike those reported for Alzheimer disease.(814) This structure is filled with innumerable autophagic”
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. (2009, background): “In AD brain, the autophagy–lysosomal system is disturbed, which may promote the accumulation of b-amyloid (24,62).”
Neuronal Cell Death. (2018, positive): “This is especially important as lysosomal activity impairment is suggested to be a major cause of cell death in Alzheimer’s disease (510, 511) and other neurodegenerative diseases (234, 615).”
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease (2010, background): “Accumulation of both ROS and AVs are early features in AD (4).”
Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations (2010, neutral): “Autophagic vacuoles (AVs), the general term for intermediate vesicular compartments in the process of autophagy, accumulate in several neurodegenerative diseases (Cuervo et al., 2004; Nixon et al., 2005; Ravikumar et al., 2004) but autophagy pathology in Alzheimer’s disease (AD) is exceptionally rob”
Immune activation in brain aging and neurodegeneration: too much or too little? (2009, background): “Autophagy is impaired in AD (Nixon et al., 2005) and is implicated in the clearance of protein aggregates associated with AD, PD, and HD (Pickford et al., 2008; Ravikumar et al., 2004; Webb et al., 2003).”
HDAC6 controls autophagosome maturation essential for ubiquitin‐selective quality‐control autophagy (2010, background): “In fact, it has been speculated that abundant autophagic structures observed in AD patients could involve a failure to form functional autophagolysosomes (Nixon et al, 2005).”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, neutral): “A large dystrophic neurite from a brain biopsy of a patient with Gerstmann-Str€aussler-Scheinker disease not unlike those reported for Alzheimer disease.(60) This structure is filled with innumerable autophagic vacuoles, some of which are covered by a double membrane.”
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. (2008, background): “Indeed, increased numbers of autophagic vacuoles have previously been identified in dystrophic neurites in brains of humans with AD (35, 48) and in APP transgenic mice (10, 35).”