Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

By Alexei Degterev, Zhihong Huang, M. Boyce, Yaqiao Li, P. Jagtap, N. Mizushima, G. Cuny, T. Mitchison, M. Moskowitz, Junying Yuan. Nature Chemical Biology, 2005

2,945 citations recorded by the source corpus.

Subfields: Endocrinology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/604173c8250d2c44163341ff99d45adf630dc995

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Citations in the corpus

Molecular mechanisms of necroptosis: an ordered cellular explosion (2010, background): “Since then, accumulating evidence has paved the way to the concept of 'programmed necrosis' ( Timeline ), culminating in the introduction, in 2005, of the neologism necroptosis to describe one instance of regulated (as opposed to accidental) necrotic cell deat”
Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research (2022, background): “Necroptosis has been pharmacologically suppressed using chemical compounds, including necrostatin-1 [34].”
T cell lipid peroxidation induces ferroptosis and prevents immunity to infection (2015, background): “ERK1/2 phosphorylation upon TCR triggering depends on the generation of hydrogen peroxide and stimulates glutamine uptake (Devadas et al., 2002; Carr et al., 2010).”
Necroptosis: Mechanisms and Relevance to Disease (2016, neutral): “Neurological disorders— Nec-1 mediates neuroprotective effects in rodent models of acute and chronic neurological conditions, including adult stroke (146), neonatal hypoxia/ ischemia (H/I) (147, 148), retinal ischemia (149), retinal detachment (150–152), subarachnoid hemorrhage (153, 154),…”
Cellular Stress Responses: Cell Survival and Cell Death (2010, background): “[69] A.”
Ischemia/Reperfusion (2016, positive): “activated by ligation of receptors in the TNF family (240) but are also critical for the progression of regulated necrotic death in response to stressful stimuli (141,175,176,234,349).”
Pattern Recognition Receptors and the Host Cell Death Molecular Machinery (2018, background): “The first molecule to be identified in the necroptotic pathway was RIPK1 as its kinase activity inhibitor, necrostatin-1 (Nec-1), was shown to suppress cell death triggered by caspase inhibition during TNFR1/Fas stimulation (39).”
Cell Death Signaling. (2015, background): “The best-characterized form of programmed necrosis is RIP-kinase-dependent necrosis (also referred to as “necroptosis”) (Degterev et al. 2005).”
Regulated cell death (RCD) in cancer: key pathways and targeted therapies (2022, background): “Therefore, the role of RIPK1 in cells can determine whether cancer cells survive or undergo necroptosis through targeted drugs.(292) RIPK3 activation of MLKL is a key regulatory pathway in necroptosis.”
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 (2011, background): “wortmannin have been widely employed in cell death research, and surely contributed to important discoveries, for example, that of regulated necrosis.(10) However, most of”
A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. (2007, background): “Nonapoptotic death mechanisms can occur concomitantly with apoptosis or can function as alternative processes when apoptosis is impaired to mediate such important developmental processes as interdigital cell death and hollowing of the mammary ducts during puberty (Chautan et al., 1999; Debnath et al”
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “, Nec-1s) robustly inhibit TNFR1-driven necroptosis, in vitro and in vivo [425, 427].”