Minireview: Gut microbiota: the neglected endocrine organ.

By G. Clarke, R. Stilling, P. Kennedy, C. Stanton, J. Cryan, Ted G. Dinan. Molecular Endocrinology, 2014

1,057 citations recorded by the source corpus.

Subfields: Gastroenterology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/eb11ba5b662835f6a58ea83a7fc7bc99c9f51f4d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Gastroenterology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. Ygor P. Silva
6. A. Bernardi
7. R. Frozza
8. Julian R. Marchesi

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. David S. Wishart
6. Ygor P. Silva
7. A. Bernardi
8. R. Frozza

In Physiology

1. David S. Wishart
2. G. Clarke
3. Ted G. Dinan
4. J. Cryan
5. Claudio Franceschi
6. M. Conte
7. H. Smidt
8. Nihal Hasan

Citations in the corpus

• Metabolomics for Investigating Physiological and Pathophysiological Processes. (2019, background): “As was noted earlier, the gut essentially functions as an endocrine organ through the regulated production and release of its microbially derived metabolites (87).”
• American Gut: an Open Platform for Citizen Science Microbiome Research (2018, neutral): “Group 1 contained samples from individuals answering “more than 30” ( n (cid:2) 41) and “less than 10” ( n (cid:2) 44) to the main American Gut Project survey question “In an average week, how many different plants do you eat?””
• Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism (2018, background): “Manipulating the gut microbial composition can modulate plasma concentrations of Trp and Trp metabolites (Clarke et al., 2014).”
• The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates (2018, background): “From this point of view it is important to note that a bidirectional axis between the brain and the GM does exist, and, importantly, GM is involved in the production of various neurotransmitters (serotonin, dopamine, noradrenaline, and GABA), and in the modulation of various behavioral and CNS funct”
• Impact of the gut microbiota on inflammation, obesity, and metabolic disease (2016, background): “In fact, the gut microbiota is even seen as a separate endocrine organ, which is involved, through a molecular crosstalk with the host, in the maintenance of host energy homeostasis and in the stimulation of host immunity [32].”
• Kynurenine pathway metabolism and the microbiota‐gut‐brain axis (2017, background): “This corresponds to a time period during pregnancy in which the maternal microbiota undergoes major remodelling (Clarke et al., 2014b) and during early life when the gut microbiota is seeded and undergoes extensive development (Borre et al., 2014; O'Mahony et al., 2015b).”
• The human gut microbiota: Metabolism and perspective in obesity (2018, background): “The gut microbiota has recently been recognized as an important factor for the development of metabolic diseases and is considered an endocrine organ involved in the maintenance of energy homeostasis and host immunity.(1) Changes in the composition of the gut microbiota due to environmental factors ”
• The gut microbiota and host health: a new clinical frontier (2015, background): “17 Three ‘ P ’ s ’ for gut health: probiotics, prebiotics and polyphenols A number of dietary strategies are available for modulating either the composition or metabolic/immunological activity of the human gut microbiota: probiotics, prebiotics and polyphenols are among the most well established.”
• Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “The gut microbiota are now considered to be a distinct organ system with endocrine properties that can directly and profoundly modulate the host immune system (722, 723).”
• Gut microbiota induce IGF-1 and promote bone formation and growth (2016, background): “These symbiotic microorganisms, known as microbiota, can be viewed as a multicellular organ that communicates with and influences the host in numerous diverse ways (2, 3).”
• The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020, background): “In particular, these SCFAs regulate the expression levels of tryptophan 5-hydroxylase 1, the enzyme involved in synthesis of serotonin, and tyrosine hydroxylase, which is involved in a rate-limiting step in the biosynthesis of dopamine, noradrenaline and adrenaline; therefore, producing an effect on”
• Factors affecting the composition of the gut microbiota, and its modulation (2019, background): “The vegetarian diet inhibits this, and fosters carbohydrate fermentation as the main function of microbiota (Tang et al., 2013; Clarke et al., 2014).”