The origin of the autophagosomal membrane

By S. Tooze, T. Yoshimori. Nature Cell Biology, 2010

613 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/02d6aa6b9267ab49606603db0fecb0f32599c134

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Citations in the corpus

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase (2011, neutral): “The initiating event in autophagy is nucleation of the membrane that will form the autophagosome (Tooze and Yoshimori, 2010), after which the microtubule-associated protein 1A/1B light chain 3 (LC3) conjugation system acts in membrane elongation and autophagosome formation (Tanida, 2010).”
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. (2012, neutral): “…step, an isolation membrane (also known as a phagophore ) is generated directly from or in close proximity to the endoplasmic reticulum (ER) and surrounds a small portion of the cytoplasm to become a double-membrane organelle, the autophagosome (Mizushima et al., 2011; Tooze and Yoshimori, 2010).”
Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “The hallmark of this process is the formation of a double membrane from internal membranes (also called phagophore), the origin of which is somewhat debated but likely being the ER with mitochondrial and possibly other membrane participation (548, 1565).”
Autophagy and autophagy-related proteins in cancer (2020, background): “onto the PAS lead to the formation of a phagophore (or an isolation membrane) [40, 41].”
Autophagy: Renovation of Cells and Tissues (2011, background): “Recent studies suggest that additional membranes derived from the Golgi complex, the mitochondria, and the plasma membrane also contribute to autophagosome formation (Hailey et al., 2010; Mizushima et al., 2011; Ravikumar et al., 2010; Tooze and Yoshimori, 2010).”
The Beclin 1 network regulates autophagy and apoptosis (2011, neutral): “Potential sources for the membrane to generate the phagophore include the Golgi complex, endosomes, the endoplasmic reticulum (ER), mitochondria and the plasma membrane.(2)”
The pathways of mitophagy for quality control and clearance of mitochondria (2012, background): “Although clearly essential for forming the defining doublemembrane vesicle of the autophagosome, the origin of the membrane component remains controversial.(26) De novo membrane assembly has been proposed; however, various studies have implicated the ER,(26,27) Golgi,(26) plasma membrane,(28) and mo”
Autophagy-Dependent Ferroptosis: Machinery and Regulation (2020, background): “, the endoplasmic reticulum [ER], mitochondria-ER associated membrane, Golgi complex, plasma membrane, and recycling endosomes) to engulf cytoplasm (Tooze and Yoshimori, 2010).”
Autophagosomes form at ER–mitochondria contact sites (2013, methodology): “1/Myc-His(2)A (Invitrogen) using engineered EcoRI and KpnI sites.”