The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes.

By Eisuke Itakura, Chieko Kishi-Itakura, N. Mizushima. Cell, 2012

1,220 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/31fdbe23f0adac5501772a33c315dd6e11d08a2d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. T. Johansen
2. T. Lamark
3. Douglas R. Green
4. N. Mizushima
5. Saori R. Yoshii
6. M. Lazarou
7. B. Padman
8. T. Nguyen

In Epidemiology

1. T. Johansen
2. T. Lamark
3. N. Mizushima
4. Douglas R. Green
5. Saori R. Yoshii
6. M. Lazarou
7. B. Padman
8. T. Nguyen

In Physiology

1. Douglas R. Green
2. T. Johansen
3. T. Lamark
4. Saori R. Yoshii
5. F. Reggiori
6. N. Mizushima
7. I. Slaninová
8. Beth Levine

Citations in the corpus

• Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion (2018, background): “Investigation of the 2 known autophagosomal SNARE proteins, STX17 and SNAP29 [53], revealed that CQ allowed recruitment of STX17, but not SNAP29, onto autophagosomes.”
• Molecular definitions of autophagy and related processes (2017, neutral): “…et al , 2016), syntaxin 17 (STX17), and other soluble N-ethylmaleimide-sensitive factor activating protein receptor (SNARE) proteins (Fader et al , 2009; Nair et al , 2011; Itakura et al , 2012), as well as homotypic fusion and vacuole protein sorting (HOPS) complexes (McEwan et al , 2015).”
• Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors. (2020, background): “The SNARE syntaxin17 (STX17) is acting both early in autophagosome formation and in autophagosome–lysosome fusion [11,47].”
• Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, neutral): “STX17 is a SNARE protein that is recruited to completely sealed autophagosomes, but not to phagophores.(584,585) As little STX17 is present on autolysosomes, STX17 is enriched on com-”
• Deciphering the Molecular Signals of PINK1/Parkin Mitophagy. (2016, background): “In mammalian cells, the autophagosomal SNARE syntaxin 17 (Stx17), SNAP-29, and the lysosomal SNARE Vamp8 function together with the homotypic fusion and protein sorting (HOPS) tethering complex to fuse autophagosomes with lysosomes [65–67].”
• Cell Death Signaling. (2015, background): “This fusion event is achieved when membranes from both organelles are brought into close proximity through interaction between the autophagosomal protein syntaxin 17 (Stx17), SNAP29, and VAMP8 on the lysosome (Itakura et al. 2012).”
• Autophagy pathway: Cellular and molecular mechanisms (2018, neutral): “SNARE complex, which mediates autophagosome-lysosome fusion.(62)”
• Monitoring and Measuring Autophagy (2017, background): “Mature autophagosomes that have acquired STX17 fuse with the lysosome to degrade their contents [23] (Figure 1D).”
• Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation (2016, methodology): “GFP-STX17 localized around mitochondria comparably in WT and all KO cell lines during mitophagy (Fig.”